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Multiparameter Flow Cytometry for the Identification of Neoplastic Plasma Cells in POEMS Syndrome with IgG-kappa Gammopathy: Successful Treatment Using Lenalidomide and Dexamethasone

A 72-year-old man presented with a 6-month history of systemic edema. Hyperpigmentation, hemangioma, pleural effusion, IgG-kappa-type monoclonal protein, high vascular endothelial growth factor values, renal failure, and nerve conduction study abnormalities were also present. Multiparameter flow cyt...

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Autores principales: Ikeda, Sho, Kobayashi, Takahiro, Saito, Masaya, Komatsuda, Atsushi, Ubukawa, Kumi, Kameoka, Yoshihiro, Takahashi, Naoto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928515/
https://www.ncbi.nlm.nih.gov/pubmed/31391391
http://dx.doi.org/10.2169/internalmedicine.2882-19
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author Ikeda, Sho
Kobayashi, Takahiro
Saito, Masaya
Komatsuda, Atsushi
Ubukawa, Kumi
Kameoka, Yoshihiro
Takahashi, Naoto
author_facet Ikeda, Sho
Kobayashi, Takahiro
Saito, Masaya
Komatsuda, Atsushi
Ubukawa, Kumi
Kameoka, Yoshihiro
Takahashi, Naoto
author_sort Ikeda, Sho
collection PubMed
description A 72-year-old man presented with a 6-month history of systemic edema. Hyperpigmentation, hemangioma, pleural effusion, IgG-kappa-type monoclonal protein, high vascular endothelial growth factor values, renal failure, and nerve conduction study abnormalities were also present. Multiparameter flow cytometry (MFC) showed 0.2% neoplastic plasma cells (CD38-, CD56-, and kappa-positive; CD19-, CD27-, and lambda-negative) in the bone marrow leading to POEMS syndrome. Cases involving kappa-type POEMS syndrome are extremely rare. A kidney biopsy revealed membranous proliferative glomerulonephritis-like changes in our case. Lenalidomide-dexamethasone therapy improved the renal function. Detection of neoplastic plasma cells by MFC was useful for the accurate diagnosis and treatment evaluation.
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spelling pubmed-69285152019-12-26 Multiparameter Flow Cytometry for the Identification of Neoplastic Plasma Cells in POEMS Syndrome with IgG-kappa Gammopathy: Successful Treatment Using Lenalidomide and Dexamethasone Ikeda, Sho Kobayashi, Takahiro Saito, Masaya Komatsuda, Atsushi Ubukawa, Kumi Kameoka, Yoshihiro Takahashi, Naoto Intern Med Case Report A 72-year-old man presented with a 6-month history of systemic edema. Hyperpigmentation, hemangioma, pleural effusion, IgG-kappa-type monoclonal protein, high vascular endothelial growth factor values, renal failure, and nerve conduction study abnormalities were also present. Multiparameter flow cytometry (MFC) showed 0.2% neoplastic plasma cells (CD38-, CD56-, and kappa-positive; CD19-, CD27-, and lambda-negative) in the bone marrow leading to POEMS syndrome. Cases involving kappa-type POEMS syndrome are extremely rare. A kidney biopsy revealed membranous proliferative glomerulonephritis-like changes in our case. Lenalidomide-dexamethasone therapy improved the renal function. Detection of neoplastic plasma cells by MFC was useful for the accurate diagnosis and treatment evaluation. The Japanese Society of Internal Medicine 2019-08-06 2019-12-01 /pmc/articles/PMC6928515/ /pubmed/31391391 http://dx.doi.org/10.2169/internalmedicine.2882-19 Text en Copyright © 2019 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Ikeda, Sho
Kobayashi, Takahiro
Saito, Masaya
Komatsuda, Atsushi
Ubukawa, Kumi
Kameoka, Yoshihiro
Takahashi, Naoto
Multiparameter Flow Cytometry for the Identification of Neoplastic Plasma Cells in POEMS Syndrome with IgG-kappa Gammopathy: Successful Treatment Using Lenalidomide and Dexamethasone
title Multiparameter Flow Cytometry for the Identification of Neoplastic Plasma Cells in POEMS Syndrome with IgG-kappa Gammopathy: Successful Treatment Using Lenalidomide and Dexamethasone
title_full Multiparameter Flow Cytometry for the Identification of Neoplastic Plasma Cells in POEMS Syndrome with IgG-kappa Gammopathy: Successful Treatment Using Lenalidomide and Dexamethasone
title_fullStr Multiparameter Flow Cytometry for the Identification of Neoplastic Plasma Cells in POEMS Syndrome with IgG-kappa Gammopathy: Successful Treatment Using Lenalidomide and Dexamethasone
title_full_unstemmed Multiparameter Flow Cytometry for the Identification of Neoplastic Plasma Cells in POEMS Syndrome with IgG-kappa Gammopathy: Successful Treatment Using Lenalidomide and Dexamethasone
title_short Multiparameter Flow Cytometry for the Identification of Neoplastic Plasma Cells in POEMS Syndrome with IgG-kappa Gammopathy: Successful Treatment Using Lenalidomide and Dexamethasone
title_sort multiparameter flow cytometry for the identification of neoplastic plasma cells in poems syndrome with igg-kappa gammopathy: successful treatment using lenalidomide and dexamethasone
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928515/
https://www.ncbi.nlm.nih.gov/pubmed/31391391
http://dx.doi.org/10.2169/internalmedicine.2882-19
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