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Association of vitamin E on the risk of ovarian cancer: a meta-analysis
Many researches were conducted to assess the association of vitamin E intake on the risk of ovarian cancer, with conflict results. The current meta-analysis of published observational studies aimed to investigate the effect of vitamin E intake on ovarian cancer risk. The summary relative risks (RRs)...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Portland Press Ltd.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928519/ https://www.ncbi.nlm.nih.gov/pubmed/31774115 http://dx.doi.org/10.1042/BSR20193311 |
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author | Leng, Youxu Zhou, Hairong Meng, Fanjing Tian, Tian Xu, Jianying Yan, Fengjuan |
author_facet | Leng, Youxu Zhou, Hairong Meng, Fanjing Tian, Tian Xu, Jianying Yan, Fengjuan |
author_sort | Leng, Youxu |
collection | PubMed |
description | Many researches were conducted to assess the association of vitamin E intake on the risk of ovarian cancer, with conflict results. The current meta-analysis of published observational studies aimed to investigate the effect of vitamin E intake on ovarian cancer risk. The summary relative risks (RRs) with corresponding 95% confidence intervals (CIs) were calculated to measure the effectiveness of vitamin E intake on ovarian cancer risk using a random-effects model. As a result, 14 studies including 4597 patients were identified. Eleven studies reported about total vitamin E intake, eight studies about vitamin E intake from food only and five studies about vitamin E intake from supplement only on the risk of ovarian cancer. Overall, the summary RRs on ovarian cancer risk was 0.95 (95%CIs = 0.78–1.16) in total vitamin E intake, 0.99 (95%CIs = 0.77–1.27) in vitamin E intake from food only and 0.82 (95%CIs = 0.54–1.25) in vitamin E intake from supplement only. Results in subgroup analyses by study design and geographic location were consistent with overall result. In conclusions, the findings of this meta-analysis suggested that high intake of vitamin E from food or vitamin E supplement had no significant effect on the risk of ovarian cancer. |
format | Online Article Text |
id | pubmed-6928519 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Portland Press Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-69285192020-01-02 Association of vitamin E on the risk of ovarian cancer: a meta-analysis Leng, Youxu Zhou, Hairong Meng, Fanjing Tian, Tian Xu, Jianying Yan, Fengjuan Biosci Rep Cancer Many researches were conducted to assess the association of vitamin E intake on the risk of ovarian cancer, with conflict results. The current meta-analysis of published observational studies aimed to investigate the effect of vitamin E intake on ovarian cancer risk. The summary relative risks (RRs) with corresponding 95% confidence intervals (CIs) were calculated to measure the effectiveness of vitamin E intake on ovarian cancer risk using a random-effects model. As a result, 14 studies including 4597 patients were identified. Eleven studies reported about total vitamin E intake, eight studies about vitamin E intake from food only and five studies about vitamin E intake from supplement only on the risk of ovarian cancer. Overall, the summary RRs on ovarian cancer risk was 0.95 (95%CIs = 0.78–1.16) in total vitamin E intake, 0.99 (95%CIs = 0.77–1.27) in vitamin E intake from food only and 0.82 (95%CIs = 0.54–1.25) in vitamin E intake from supplement only. Results in subgroup analyses by study design and geographic location were consistent with overall result. In conclusions, the findings of this meta-analysis suggested that high intake of vitamin E from food or vitamin E supplement had no significant effect on the risk of ovarian cancer. Portland Press Ltd. 2019-12-23 /pmc/articles/PMC6928519/ /pubmed/31774115 http://dx.doi.org/10.1042/BSR20193311 Text en © 2019 The Author(s). https://creativecommons.org/licenses/by/4.0/ This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY). |
spellingShingle | Cancer Leng, Youxu Zhou, Hairong Meng, Fanjing Tian, Tian Xu, Jianying Yan, Fengjuan Association of vitamin E on the risk of ovarian cancer: a meta-analysis |
title | Association of vitamin E on the risk of ovarian cancer: a meta-analysis |
title_full | Association of vitamin E on the risk of ovarian cancer: a meta-analysis |
title_fullStr | Association of vitamin E on the risk of ovarian cancer: a meta-analysis |
title_full_unstemmed | Association of vitamin E on the risk of ovarian cancer: a meta-analysis |
title_short | Association of vitamin E on the risk of ovarian cancer: a meta-analysis |
title_sort | association of vitamin e on the risk of ovarian cancer: a meta-analysis |
topic | Cancer |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928519/ https://www.ncbi.nlm.nih.gov/pubmed/31774115 http://dx.doi.org/10.1042/BSR20193311 |
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