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Pioglitazone protects blood vessels through inhibition of the apelin signaling pathway by promoting KLF4 expression in rat models of T2DM

Apelin, identified as the endogenous ligand of APJ, exerts various cardiovascular effects. However, the molecular mechanism underlying the regulation of apelin expression in vascular cells is poorly described. Pioglitazone (PIO) and Krüppel-like factor 4 (KLF4) exhibit specific biological functions...

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Detalles Bibliográficos
Autores principales:	Wang, Ying, Zhang, Ruonan, Shen, Hailin, Kong, Jing, Lv, Xinrui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2019
Materias:	Cardiovascular System & Vascular Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928522/ https://www.ncbi.nlm.nih.gov/pubmed/31829402 http://dx.doi.org/10.1042/BSR20190317

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