TRIM proteins in neuroblastoma

Neuroblastoma (NB) is the most common extracranial solid tumor in childhood. Outcome for children with high-risk NB remains unsatisfactory. Accumulating evidence suggests that tripartite motif (TRIM) family proteins express diversely in various human cancers and act as regulators of oncoproteins or...

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Detalles Bibliográficos
Autores principales: Xu, Yonghu, Zhang, Zihan, Xu, Guofeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2019
Materias:
Cancer
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928532/
https://www.ncbi.nlm.nih.gov/pubmed/31820796
http://dx.doi.org/10.1042/BSR20192050
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author Xu, Yonghu
Zhang, Zihan
Xu, Guofeng
author_facet Xu, Yonghu
Zhang, Zihan
Xu, Guofeng
author_sort Xu, Yonghu
collection PubMed
description Neuroblastoma (NB) is the most common extracranial solid tumor in childhood. Outcome for children with high-risk NB remains unsatisfactory. Accumulating evidence suggests that tripartite motif (TRIM) family proteins express diversely in various human cancers and act as regulators of oncoproteins or tumor suppressor proteins. This review summarizes the TRIM proteins involving in NB and the underlying molecular mechanisms. We expect these new insights will provide important implications for the treatment of NB by targeting TRIM proteins.
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spelling pubmed-69285322020-01-02 TRIM proteins in neuroblastoma Xu, Yonghu Zhang, Zihan Xu, Guofeng Biosci Rep Cancer Neuroblastoma (NB) is the most common extracranial solid tumor in childhood. Outcome for children with high-risk NB remains unsatisfactory. Accumulating evidence suggests that tripartite motif (TRIM) family proteins express diversely in various human cancers and act as regulators of oncoproteins or tumor suppressor proteins. This review summarizes the TRIM proteins involving in NB and the underlying molecular mechanisms. We expect these new insights will provide important implications for the treatment of NB by targeting TRIM proteins. Portland Press Ltd. 2019-12-23 /pmc/articles/PMC6928532/ /pubmed/31820796 http://dx.doi.org/10.1042/BSR20192050 Text en © 2019 The Author(s). https://creativecommons.org/licenses/by/4.0/ This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY).
spellingShingle Cancer
Xu, Yonghu
Zhang, Zihan
Xu, Guofeng
TRIM proteins in neuroblastoma
title TRIM proteins in neuroblastoma
title_full TRIM proteins in neuroblastoma
title_fullStr TRIM proteins in neuroblastoma
title_full_unstemmed TRIM proteins in neuroblastoma
title_short TRIM proteins in neuroblastoma
title_sort trim proteins in neuroblastoma
topic Cancer
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928532/
https://www.ncbi.nlm.nih.gov/pubmed/31820796
http://dx.doi.org/10.1042/BSR20192050
work_keys_str_mv AT xuyonghu trimproteinsinneuroblastoma
AT zhangzihan trimproteinsinneuroblastoma
AT xuguofeng trimproteinsinneuroblastoma

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