Immunogenicity of chimeric haemagglutinin-based, universal influenza virus vaccine candidates: interim results of a randomised, placebo-controlled, phase 1 clinical trial

BACKGROUND: Influenza viruses cause substantial annual morbidity and mortality globally. Current vaccines protect against influenza only when well matched to the circulating strains. However, antigenic drift can cause considerable mismatches between vaccine and circulating strains, substantially red...

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Detalles Bibliográficos
Autores principales: Bernstein, David I, Guptill, Jeffrey, Naficy, Abdollah, Nachbagauer, Raffael, Berlanda-Scorza, Francesco, Feser, Jodi, Wilson, Patrick C, Solórzano, Alicia, Van der Wielen, Marie, Walter, Emmanuel B, Albrecht, Randy A, Buschle, Kristen N, Chen, Yao-qing, Claeys, Carine, Dickey, Michelle, Dugan, Haley L, Ermler, Megan E, Freeman, Debra, Gao, Min, Gast, Christopher, Guthmiller, Jenna J, Hai, Rong, Henry, Carole, Lan, Linda Yu-Ling, McNeal, Monica, Palm, Anna-Karin E, Shaw, Dustin G, Stamper, Christopher T, Sun, Weina, Sutton, Victoria, Tepora, Micah E, Wahid, Rahnuma, Wenzel, Heather, Wohlbold, Teddy John, Innis, Bruce L, García-Sastre, Adolfo, Palese, Peter, Krammer, Florian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928577/
https://www.ncbi.nlm.nih.gov/pubmed/31630990
http://dx.doi.org/10.1016/S1473-3099(19)30393-7

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