Functional Impacts of the BRCA1-mTORC2 Interaction in Breast Cancer

Deleterious mutations in Breast Cancer 1 (BRCA1) are associated with an increased risk of breast and ovarian cancer. Mutations in the tandem BRCA1 C-terminal (tBRCT) protein domain disrupt critical protein interactions required for the faithful repair of DNA through homologous recombination, which c...

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Detalles Bibliográficos
Autores principales: Krieger, Kimiko L., Hu, Wen-Feng, Ripperger, Tyler, Woods, Nicholas T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928641/
https://www.ncbi.nlm.nih.gov/pubmed/31771139
http://dx.doi.org/10.3390/ijms20235876

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928641/
https://www.ncbi.nlm.nih.gov/pubmed/31771139
http://dx.doi.org/10.3390/ijms20235876

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