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microRNAs Tune Oxidative Stress in Cancer Therapeutic Tolerance and Resistance
Relapsed disease following first-line therapy remains one of the central problems in cancer management, including chemotherapy, radiotherapy, growth factor receptor-based targeted therapy, and immune checkpoint-based immunotherapy. Cancer cells develop therapeutic resistance through both intrinsic a...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2019
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928693/ https://www.ncbi.nlm.nih.gov/pubmed/31816897 http://dx.doi.org/10.3390/ijms20236094 |
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author | Zhang, Wen Cai |
author_facet | Zhang, Wen Cai |
author_sort | Zhang, Wen Cai |
collection | PubMed |
description | Relapsed disease following first-line therapy remains one of the central problems in cancer management, including chemotherapy, radiotherapy, growth factor receptor-based targeted therapy, and immune checkpoint-based immunotherapy. Cancer cells develop therapeutic resistance through both intrinsic and extrinsic mechanisms including cellular heterogeneity, drug tolerance, bypassing alternative signaling pathways, as well as the acquisition of new genetic mutations. Reactive oxygen species (ROSs) are byproducts originated from cellular oxidative metabolism. Recent discoveries have shown that a disabled antioxidant program leads to therapeutic resistance in several types of cancers. ROSs are finely tuned by dysregulated microRNAs, and vice versa. However, mechanisms of a crosstalk between ROSs and microRNAs in regulating therapeutic resistance are not clear. Here, we summarize how the microRNA–ROS network modulates cancer therapeutic tolerance and resistance and direct new vulnerable targets against drug tolerance and resistance for future applications. |
format | Online Article Text |
id | pubmed-6928693 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-69286932019-12-26 microRNAs Tune Oxidative Stress in Cancer Therapeutic Tolerance and Resistance Zhang, Wen Cai Int J Mol Sci Review Relapsed disease following first-line therapy remains one of the central problems in cancer management, including chemotherapy, radiotherapy, growth factor receptor-based targeted therapy, and immune checkpoint-based immunotherapy. Cancer cells develop therapeutic resistance through both intrinsic and extrinsic mechanisms including cellular heterogeneity, drug tolerance, bypassing alternative signaling pathways, as well as the acquisition of new genetic mutations. Reactive oxygen species (ROSs) are byproducts originated from cellular oxidative metabolism. Recent discoveries have shown that a disabled antioxidant program leads to therapeutic resistance in several types of cancers. ROSs are finely tuned by dysregulated microRNAs, and vice versa. However, mechanisms of a crosstalk between ROSs and microRNAs in regulating therapeutic resistance are not clear. Here, we summarize how the microRNA–ROS network modulates cancer therapeutic tolerance and resistance and direct new vulnerable targets against drug tolerance and resistance for future applications. MDPI 2019-12-03 /pmc/articles/PMC6928693/ /pubmed/31816897 http://dx.doi.org/10.3390/ijms20236094 Text en © 2019 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Zhang, Wen Cai microRNAs Tune Oxidative Stress in Cancer Therapeutic Tolerance and Resistance |
title | microRNAs Tune Oxidative Stress in Cancer Therapeutic Tolerance and Resistance |
title_full | microRNAs Tune Oxidative Stress in Cancer Therapeutic Tolerance and Resistance |
title_fullStr | microRNAs Tune Oxidative Stress in Cancer Therapeutic Tolerance and Resistance |
title_full_unstemmed | microRNAs Tune Oxidative Stress in Cancer Therapeutic Tolerance and Resistance |
title_short | microRNAs Tune Oxidative Stress in Cancer Therapeutic Tolerance and Resistance |
title_sort | micrornas tune oxidative stress in cancer therapeutic tolerance and resistance |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928693/ https://www.ncbi.nlm.nih.gov/pubmed/31816897 http://dx.doi.org/10.3390/ijms20236094 |
work_keys_str_mv | AT zhangwencai micrornastuneoxidativestressincancertherapeutictoleranceandresistance |