Cargando…

In Human and Mouse Spino-Cerebellar Tissue, Ataxin-2 Expansion Affects Ceramide-Sphingomyelin Metabolism

Ataxin-2 (human gene symbol ATXN2) acts during stress responses, modulating mRNA translation and nutrient metabolism. Ataxin-2 knockout mice exhibit progressive obesity, dyslipidemia, and insulin resistance. Conversely, the progressive ATXN2 gain of function due to the fact of polyglutamine (polyQ)...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sen, Nesli-Ece, Arsovic, Aleksandar, Meierhofer, David, Brodesser, Susanne, Oberschmidt, Carola, Canet-Pons, Júlia, Kaya, Zeynep-Ece, Halbach, Melanie-Vanessa, Gispert, Suzana, Sandhoff, Konrad, Auburger, Georg
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928749/ https://www.ncbi.nlm.nih.gov/pubmed/31766565 http://dx.doi.org/10.3390/ijms20235854

Ejemplares similares

Mouse Ataxin-2 Expansion Downregulates CamKII and Other Calcium Signaling Factors, Impairing Granule—Purkinje Neuron Synaptic Strength
por: Arsović, Aleksandar, et al.
Publicado: (2020)

PINK1 and Ataxin-2 as modifiers of growth
por: Sen, Nesli E., et al.
Publicado: (2017)

Systematic Surveys of Iron Homeostasis Mechanisms Reveal Ferritin Superfamily and Nucleotide Surveillance Regulation to be Modified by PINK1 Absence
por: Key, Jana, et al.
Publicado: (2020)

SerThr-PhosphoProteome of Brain from Aged PINK1-KO+A53T-SNCA Mice Reveals pT1928-MAP1B and pS3781-ANK2 Deficits, as Hub between Autophagy and Synapse Changes
por: Auburger, Georg, et al.
Publicado: (2019)

Mid-Gestation lethality of Atxn2l-Ablated Mice
por: Key, Jana, et al.
Publicado: (2020)

An update on Spino-cerebellar ataxias
por: Mondal, Banashree, et al.
Publicado: (2013)

TR-FRET-Based Immunoassay to Measure Ataxin-2 as a Target Engagement Marker in Spinocerebellar Ataxia Type 2
por: Bux, Jessica, et al.
Publicado: (2023)

Genetic ablation of ataxin-2 increases several global translation factors in their transcript abundance but decreases translation rate
por: Fittschen, M., et al.
Publicado: (2015)

Ceramide/Sphingomyelin Rheostat Regulated by Sphingomyelin Synthases and Chronic Diseases in Murine Models
por: Taniguchi, Makoto, et al.
Publicado: (2020)

Both Ubiquitin Ligases FBXW8 and PARK2 Are Sequestrated into Insolubility by ATXN2 PolyQ Expansions, but Only FBXW8 Expression Is Dysregulated
por: Halbach, Melanie Vanessa, et al.
Publicado: (2015)

The Role of Sphingomyelin and Ceramide in Motor Neuron Diseases
por: McCluskey, Gavin, et al.
Publicado: (2022)

Sphingomyelin synthase 2 promotes an aggressive breast cancer phenotype by disrupting the homoeostasis of ceramide and sphingomyelin
por: Zheng, Kehong, et al.
Publicado: (2019)

Antidepressants act by inducing autophagy controlled by sphingomyelin–ceramide
por: Gulbins, Anne, et al.
Publicado: (2018)

Atxn2 Knockout and CAG42-Knock-in Cerebellum Shows Similarly Dysregulated Expression in Calcium Homeostasis Pathway
por: Halbach, Melanie Vanessa, et al.
Publicado: (2016)

Role of membrane sphingomyelin and ceramide in platform formation for Fas-mediated apoptosis
por: Miyaji, Michihiko, et al.
Publicado: (2005)

Sphingomyelin synthase-related protein SMSr controls ceramide homeostasis in the ER
por: Vacaru, Ana M., et al.
Publicado: (2009)

Early postoperative changes of sphingomyelins and ceramides after laparoscopic sleeve gastrectomy
por: Özer, Hakan, et al.
Publicado: (2018)

Exploring polar headgroup interactions between sphingomyelin and ceramide with infrared spectroscopy
por: de la Arada, Igor, et al.
Publicado: (2020)

Plasma Ceramides and Sphingomyelins and Sudden Cardiac Death in the Cardiovascular Health Study
por: Bockus, Lee B., et al.
Publicado: (2023)

Ceramide from sphingomyelin hydrolysis induces neuronal differentiation, whereas de novo ceramide synthesis and sphingomyelin hydrolysis initiate apoptosis after NGF withdrawal in PC12 Cells
por: Kagan, Terri, et al.
Publicado: (2022)

Direct and indirect spino-cerebellar pathways: shared ideas but different functions in motor control
por: Jiang, Juan, et al.
Publicado: (2015)

Plasma Ceramides and Sphingomyelins in Relation to Atrial Fibrillation Risk: The Cardiovascular Health Study
por: Jensen, Paul N., et al.
Publicado: (2020)

Requirement for Zebrafish Ataxin-7 in Differentiation of Photoreceptors and Cerebellar Neurons
por: Yanicostas, Constantin, et al.
Publicado: (2012)

Increased presence of nuclear DNAJA3 and upregulation of cytosolic STAT1 and of nucleic acid sensors trigger innate immunity in the ClpP-null mouse
por: Maletzko, Antonia, et al.
Publicado: (2021)

Progression of pathology in PINK1-deficient mouse brain from splicing via ubiquitination, ER stress, and mitophagy changes to neuroinflammation
por: Torres-Odio, Sylvia, et al.
Publicado: (2017)

Chronic Ethanol Consumption Profoundly Alters Regional Brain Ceramide and Sphingomyelin Content in Rodents
por: Roux, Aurelie, et al.
Publicado: (2014)

Translational Approaches Targeting Ceramide Generation From Sphingomyelin in T Cells to Modulate Immunity in Humans
por: Hollmann, Claudia, et al.
Publicado: (2019)

Sphingomyelin synthase-related protein generates diacylglycerol via the hydrolysis of glycerophospholipids in the absence of ceramide
por: Murakami, Chiaki, et al.
Publicado: (2021)

On Spinal and Spino-Gangleal Irritation
Publicado: (1831)

The Spino-Parabrachial Pathway for Itch
por: Piyush Shah, Devanshi, et al.
Publicado: (2022)

Methyl-Arginine Profile of Brain from Aged PINK1-KO+A53T-SNCA Mice Suggests Altered Mitochondrial Biogenesis
por: Auburger, Georg, et al.
Publicado: (2016)

The Bacterial ClpXP-ClpB Family Is Enriched with RNA-Binding Protein Complexes
por: Auburger, Georg, et al.
Publicado: (2022)

Altered levels of serum sphingomyelin and ceramide containing distinct acyl chains in young obese adults
por: Hanamatsu, H, et al.
Publicado: (2014)

Milk polar lipids favorably alter circulating and intestinal ceramide and sphingomyelin species in postmenopausal women
por: Le Barz, Mélanie, et al.
Publicado: (2021)

Multi-Omic analyses characterize the ceramide/sphingomyelin pathway as a therapeutic target in Alzheimer’s disease
por: Baloni, Priyanka, et al.
Publicado: (2022)

A tissue‐specific screen of ceramide expression in aged mice identifies ceramide synthase‐1 and ceramide synthase‐5 as potential regulators of fiber size and strength in skeletal muscle
por: Tosetti, Bettina, et al.
Publicado: (2019)

Major Depressive Disorder - A co-morbid condition in a case of spino-cerebellar ataxia with writer's cramp
por: Mohapatra, Prasanta Kumar, et al.
Publicado: (2003)

The spino-bulbar-cerebellar pathway: organization and neurochemical properties of spinal cells that project to the lateral reticular nucleus in the rat
por: Huma, Zilli, et al.
Publicado: (2015)

Effects of the administration of Elovl5-dependent fatty acids on a spino-cerebellar ataxia 38 mouse model
por: Balbo, Ilaria, et al.
Publicado: (2022)

Circulating ceramides and sphingomyelins and the risk of incident cardiovascular disease among people with diabetes: the strong heart study
por: Jensen, Paul N., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_kuootci9gt1858sqfqvl8amt06