CGRP Signaling via CALCRL Increases Chemotherapy Resistance and Stem Cell Properties in Acute Myeloid Leukemia

The neuropeptide CGRP, acting through the G-protein coupled receptor CALCRL and its coreceptor RAMP1, plays a key role in migraines, which has led to the clinical development of several inhibitory compounds. Recently, high CALCRL expression has been shown to be associated with a poor prognosis in ac...

Descripción completa

Detalles Bibliográficos
Autores principales: Gluexam, Tobias, Grandits, Alexander M., Schlerka, Angela, Nguyen, Chi Huu, Etzler, Julia, Finkes, Thomas, Fuchs, Michael, Scheid, Christoph, Heller, Gerwin, Hackl, Hubert, Harrer, Nathalie, Sill, Heinz, Koller, Elisabeth, Stoiber, Dagmar, Sommergruber, Wolfgang, Wieser, Rotraud
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928760/
https://www.ncbi.nlm.nih.gov/pubmed/31756985
http://dx.doi.org/10.3390/ijms20235826

Ejemplares similares

Ejemplares similares