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Chitosan as a Wound Dressing Starting Material: Antimicrobial Properties and Mode of Action

Fighting bacterial resistance is one of the concerns in modern days, as antibiotics remain the main resource of bacterial control. Data shows that for every antibiotic developed, there is a microorganism that becomes resistant to it. Natural polymers, as the source of antibacterial agents, offer a n...

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Autores principales: Matica, Mariana Adina, Aachmann, Finn Lillelund, Tøndervik, Anne, Sletta, Håvard, Ostafe, Vasile
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928789/
https://www.ncbi.nlm.nih.gov/pubmed/31771245
http://dx.doi.org/10.3390/ijms20235889
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author Matica, Mariana Adina
Aachmann, Finn Lillelund
Tøndervik, Anne
Sletta, Håvard
Ostafe, Vasile
author_facet Matica, Mariana Adina
Aachmann, Finn Lillelund
Tøndervik, Anne
Sletta, Håvard
Ostafe, Vasile
author_sort Matica, Mariana Adina
collection PubMed
description Fighting bacterial resistance is one of the concerns in modern days, as antibiotics remain the main resource of bacterial control. Data shows that for every antibiotic developed, there is a microorganism that becomes resistant to it. Natural polymers, as the source of antibacterial agents, offer a new way to fight bacterial infection. The advantage over conventional synthetic antibiotics is that natural antimicrobial agents are biocompatible, non-toxic, and inexpensive. Chitosan is one of the natural polymers that represent a very promising source for the development of antimicrobial agents. In addition, chitosan is biodegradable, non-toxic, and most importantly, promotes wound healing, features that makes it suitable as a starting material for wound dressings. This paper reviews the antimicrobial properties of chitosan and describes the mechanisms of action toward microbial cells as well as the interactions with mammalian cells in terms of wound healing process. Finally, the applications of chitosan as a wound-dressing material are discussed along with the current status of chitosan-based wound dressings existing on the market.
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spelling pubmed-69287892019-12-26 Chitosan as a Wound Dressing Starting Material: Antimicrobial Properties and Mode of Action Matica, Mariana Adina Aachmann, Finn Lillelund Tøndervik, Anne Sletta, Håvard Ostafe, Vasile Int J Mol Sci Review Fighting bacterial resistance is one of the concerns in modern days, as antibiotics remain the main resource of bacterial control. Data shows that for every antibiotic developed, there is a microorganism that becomes resistant to it. Natural polymers, as the source of antibacterial agents, offer a new way to fight bacterial infection. The advantage over conventional synthetic antibiotics is that natural antimicrobial agents are biocompatible, non-toxic, and inexpensive. Chitosan is one of the natural polymers that represent a very promising source for the development of antimicrobial agents. In addition, chitosan is biodegradable, non-toxic, and most importantly, promotes wound healing, features that makes it suitable as a starting material for wound dressings. This paper reviews the antimicrobial properties of chitosan and describes the mechanisms of action toward microbial cells as well as the interactions with mammalian cells in terms of wound healing process. Finally, the applications of chitosan as a wound-dressing material are discussed along with the current status of chitosan-based wound dressings existing on the market. MDPI 2019-11-24 /pmc/articles/PMC6928789/ /pubmed/31771245 http://dx.doi.org/10.3390/ijms20235889 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Matica, Mariana Adina
Aachmann, Finn Lillelund
Tøndervik, Anne
Sletta, Håvard
Ostafe, Vasile
Chitosan as a Wound Dressing Starting Material: Antimicrobial Properties and Mode of Action
title Chitosan as a Wound Dressing Starting Material: Antimicrobial Properties and Mode of Action
title_full Chitosan as a Wound Dressing Starting Material: Antimicrobial Properties and Mode of Action
title_fullStr Chitosan as a Wound Dressing Starting Material: Antimicrobial Properties and Mode of Action
title_full_unstemmed Chitosan as a Wound Dressing Starting Material: Antimicrobial Properties and Mode of Action
title_short Chitosan as a Wound Dressing Starting Material: Antimicrobial Properties and Mode of Action
title_sort chitosan as a wound dressing starting material: antimicrobial properties and mode of action
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928789/
https://www.ncbi.nlm.nih.gov/pubmed/31771245
http://dx.doi.org/10.3390/ijms20235889
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