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Design and Analyses of a Transdermal Drug Delivery Device (TD(3)) †
In this paper, we introduce a novel type of transdermal drug delivery device (TD(3)) with a micro-electro-mechanical system (MEMS) design using computer-aided design (CAD) techniques as well as computational fluid dynamics (CFD) simulations regarding the fluid interaction inside the device during th...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928847/ https://www.ncbi.nlm.nih.gov/pubmed/31766416 http://dx.doi.org/10.3390/s19235090 |
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author | García, Jennifer Ríos, Ismael Fonthal Rico, Faruk |
author_facet | García, Jennifer Ríos, Ismael Fonthal Rico, Faruk |
author_sort | García, Jennifer |
collection | PubMed |
description | In this paper, we introduce a novel type of transdermal drug delivery device (TD(3)) with a micro-electro-mechanical system (MEMS) design using computer-aided design (CAD) techniques as well as computational fluid dynamics (CFD) simulations regarding the fluid interaction inside the device during the actuation process. For the actuation principles of the chamber and microvalve, both thermopneumatic and piezoelectric principles are employed respectively, originating that the design perfectly integrates those principles through two different components, such as a micropump with integrated microvalves and a microneedle array. The TD(3) has shown to be capable of delivering a volumetric flow of 2.92 × 10(−5) cm(3)/s with a 6.6 Hz membrane stroke frequency. The device only needs 116 Pa to complete the suction process and 2560 Pa to complete the discharge process. A 38-microneedle array with 450 µm in length fulfills the function of permeating skin, allowing that the fluid reaches the desired destination and avoiding any possible pain during the insertion. |
format | Online Article Text |
id | pubmed-6928847 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-69288472019-12-26 Design and Analyses of a Transdermal Drug Delivery Device (TD(3)) † García, Jennifer Ríos, Ismael Fonthal Rico, Faruk Sensors (Basel) Article In this paper, we introduce a novel type of transdermal drug delivery device (TD(3)) with a micro-electro-mechanical system (MEMS) design using computer-aided design (CAD) techniques as well as computational fluid dynamics (CFD) simulations regarding the fluid interaction inside the device during the actuation process. For the actuation principles of the chamber and microvalve, both thermopneumatic and piezoelectric principles are employed respectively, originating that the design perfectly integrates those principles through two different components, such as a micropump with integrated microvalves and a microneedle array. The TD(3) has shown to be capable of delivering a volumetric flow of 2.92 × 10(−5) cm(3)/s with a 6.6 Hz membrane stroke frequency. The device only needs 116 Pa to complete the suction process and 2560 Pa to complete the discharge process. A 38-microneedle array with 450 µm in length fulfills the function of permeating skin, allowing that the fluid reaches the desired destination and avoiding any possible pain during the insertion. MDPI 2019-11-21 /pmc/articles/PMC6928847/ /pubmed/31766416 http://dx.doi.org/10.3390/s19235090 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article García, Jennifer Ríos, Ismael Fonthal Rico, Faruk Design and Analyses of a Transdermal Drug Delivery Device (TD(3)) † |
title | Design and Analyses of a Transdermal Drug Delivery Device (TD(3)) † |
title_full | Design and Analyses of a Transdermal Drug Delivery Device (TD(3)) † |
title_fullStr | Design and Analyses of a Transdermal Drug Delivery Device (TD(3)) † |
title_full_unstemmed | Design and Analyses of a Transdermal Drug Delivery Device (TD(3)) † |
title_short | Design and Analyses of a Transdermal Drug Delivery Device (TD(3)) † |
title_sort | design and analyses of a transdermal drug delivery device (td(3)) † |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928847/ https://www.ncbi.nlm.nih.gov/pubmed/31766416 http://dx.doi.org/10.3390/s19235090 |
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