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Promising Therapeutic Efficacy of GC1118, an Anti-EGFR Antibody, against KRAS Mutation-Driven Colorectal Cancer Patient-Derived Xenografts

Epidermal growth factor receptor (EGFR)-targeted monoclonal antibodies, including cetuximab and panitumumab, are used to treat metastatic colorectal cancer (mCRC). However, this treatment is only effective for a small subset of mCRC patients positive for the wild-type KRAS GTPase. GC1118 is a novel,...

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Detalles Bibliográficos
Autores principales:	Lee, Hye Won, Son, Eunju, Lee, Kyoungmin, Lee, Yeri, Kim, Yejin, Lee, Jae-Chul, Lim, Yangmi, Hur, Minkyu, Kim, Donggeon, Nam, Do-Hyun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928876/ https://www.ncbi.nlm.nih.gov/pubmed/31771279 http://dx.doi.org/10.3390/ijms20235894

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