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Multipotent Neurotrophic Effects of Hepatocyte Growth Factor in Spinal Cord Injury

Spinal cord injury (SCI) results in neural tissue loss and so far untreatable functional impairment. In addition, at the initial injury site, inflammation induces secondary damage, and glial scar formation occurs to limit inflammation-mediated tissue damage. Consequently, it obstructs neural regener...

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Autores principales: Yamane, Kentaro, Misawa, Haruo, Takigawa, Tomoyuki, Ito, Yoshihiro, Ozaki, Toshifumi, Matsukawa, Akihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928986/
https://www.ncbi.nlm.nih.gov/pubmed/31810304
http://dx.doi.org/10.3390/ijms20236078
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author Yamane, Kentaro
Misawa, Haruo
Takigawa, Tomoyuki
Ito, Yoshihiro
Ozaki, Toshifumi
Matsukawa, Akihiro
author_facet Yamane, Kentaro
Misawa, Haruo
Takigawa, Tomoyuki
Ito, Yoshihiro
Ozaki, Toshifumi
Matsukawa, Akihiro
author_sort Yamane, Kentaro
collection PubMed
description Spinal cord injury (SCI) results in neural tissue loss and so far untreatable functional impairment. In addition, at the initial injury site, inflammation induces secondary damage, and glial scar formation occurs to limit inflammation-mediated tissue damage. Consequently, it obstructs neural regeneration. Many studies have been conducted in the field of SCI; however, no satisfactory treatment has been established to date. Hepatocyte growth factor (HGF) is one of the neurotrophic growth factors and has been listed as a candidate medicine for SCI treatment. The highlighted effects of HGF on neural regeneration are associated with its anti-inflammatory and anti-fibrotic activities. Moreover, HGF exerts positive effects on transplanted stem cell differentiation into neurons. This paper reviews the mechanisms underlying the therapeutic effects of HGF in SCI recovery, and introduces recent advances in the clinical applications of HGF therapy.
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spelling pubmed-69289862019-12-26 Multipotent Neurotrophic Effects of Hepatocyte Growth Factor in Spinal Cord Injury Yamane, Kentaro Misawa, Haruo Takigawa, Tomoyuki Ito, Yoshihiro Ozaki, Toshifumi Matsukawa, Akihiro Int J Mol Sci Review Spinal cord injury (SCI) results in neural tissue loss and so far untreatable functional impairment. In addition, at the initial injury site, inflammation induces secondary damage, and glial scar formation occurs to limit inflammation-mediated tissue damage. Consequently, it obstructs neural regeneration. Many studies have been conducted in the field of SCI; however, no satisfactory treatment has been established to date. Hepatocyte growth factor (HGF) is one of the neurotrophic growth factors and has been listed as a candidate medicine for SCI treatment. The highlighted effects of HGF on neural regeneration are associated with its anti-inflammatory and anti-fibrotic activities. Moreover, HGF exerts positive effects on transplanted stem cell differentiation into neurons. This paper reviews the mechanisms underlying the therapeutic effects of HGF in SCI recovery, and introduces recent advances in the clinical applications of HGF therapy. MDPI 2019-12-02 /pmc/articles/PMC6928986/ /pubmed/31810304 http://dx.doi.org/10.3390/ijms20236078 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Yamane, Kentaro
Misawa, Haruo
Takigawa, Tomoyuki
Ito, Yoshihiro
Ozaki, Toshifumi
Matsukawa, Akihiro
Multipotent Neurotrophic Effects of Hepatocyte Growth Factor in Spinal Cord Injury
title Multipotent Neurotrophic Effects of Hepatocyte Growth Factor in Spinal Cord Injury
title_full Multipotent Neurotrophic Effects of Hepatocyte Growth Factor in Spinal Cord Injury
title_fullStr Multipotent Neurotrophic Effects of Hepatocyte Growth Factor in Spinal Cord Injury
title_full_unstemmed Multipotent Neurotrophic Effects of Hepatocyte Growth Factor in Spinal Cord Injury
title_short Multipotent Neurotrophic Effects of Hepatocyte Growth Factor in Spinal Cord Injury
title_sort multipotent neurotrophic effects of hepatocyte growth factor in spinal cord injury
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928986/
https://www.ncbi.nlm.nih.gov/pubmed/31810304
http://dx.doi.org/10.3390/ijms20236078
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