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Circulating CRP Levels Are Associated with Epicardial and Visceral Fat Depots in Women with Metabolic Syndrome Criteria

Sexual dimorphism accounts for significant differences in adipose tissue mass and distribution. However, how the crosstalk between visceral and ectopic fat depots occurs and which are the determinants of ectopic fat expansion and dysfunction remains unknown. Here, we focused on the impact of gender...

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Autores principales: Carbone, Federico, Lattanzio, Maria Stefania, Minetti, Silvia, Ansaldo, Anna Maria, Ferrara, Daniele, Molina-Molina, Emilio, Belfiore, Anna, Elia, Edoardo, Pugliese, Stefania, Palmieri, Vincenzo Ostilio, Montecucco, Fabrizio, Portincasa, Piero
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6929041/
https://www.ncbi.nlm.nih.gov/pubmed/31783662
http://dx.doi.org/10.3390/ijms20235981
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author Carbone, Federico
Lattanzio, Maria Stefania
Minetti, Silvia
Ansaldo, Anna Maria
Ferrara, Daniele
Molina-Molina, Emilio
Belfiore, Anna
Elia, Edoardo
Pugliese, Stefania
Palmieri, Vincenzo Ostilio
Montecucco, Fabrizio
Portincasa, Piero
author_facet Carbone, Federico
Lattanzio, Maria Stefania
Minetti, Silvia
Ansaldo, Anna Maria
Ferrara, Daniele
Molina-Molina, Emilio
Belfiore, Anna
Elia, Edoardo
Pugliese, Stefania
Palmieri, Vincenzo Ostilio
Montecucco, Fabrizio
Portincasa, Piero
author_sort Carbone, Federico
collection PubMed
description Sexual dimorphism accounts for significant differences in adipose tissue mass and distribution. However, how the crosstalk between visceral and ectopic fat depots occurs and which are the determinants of ectopic fat expansion and dysfunction remains unknown. Here, we focused on the impact of gender in the crosstalk between visceral and epicardial fat depots and the role of adipocytokines and high-sensitivity C-reactive protein (hs-CRP). A total of 141 outward patients (both men and women) with one or more defining criteria for metabolic syndrome (MetS) were consecutively enrolled. For all patients, demographic and clinical data were collected and ultrasound assessment of visceral adipose tissue (VFth) and epicardial fat (EFth) thickness was performed. Hs-CRP and adipocytokine levels were assessed by enzyme-linked immunosorbent assay (ELISA). Men were characterized by increased VFth and EFth (p-value < 0.001 and 0.014, respectively), whereas women showed higher levels of adiponectin and leptin (p-value < 0.001 for both). However, only in women VFth and EFth significantly correlated between them (p = 0.013) and also with leptin (p < 0.001 for both) and hs-CRP (p = 0.005 and p = 0.028, respectively). Linear regression confirmed an independent association of both leptin and hs-CRP with VFth in women, also after adjustment for age and MetS (p = 0.012 and 0.007, respectively). In conclusion, men and women present differences in epicardial fat deposition and systemic inflammation. An intriguing association between visceral/epicardial fat depots and chronic low-grade inflammation also emerged. In women Although a further validation in larger studies is needed, these findings suggest a critical role of sex in stratification of obese/dysmetabolic patients.
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spelling pubmed-69290412019-12-26 Circulating CRP Levels Are Associated with Epicardial and Visceral Fat Depots in Women with Metabolic Syndrome Criteria Carbone, Federico Lattanzio, Maria Stefania Minetti, Silvia Ansaldo, Anna Maria Ferrara, Daniele Molina-Molina, Emilio Belfiore, Anna Elia, Edoardo Pugliese, Stefania Palmieri, Vincenzo Ostilio Montecucco, Fabrizio Portincasa, Piero Int J Mol Sci Article Sexual dimorphism accounts for significant differences in adipose tissue mass and distribution. However, how the crosstalk between visceral and ectopic fat depots occurs and which are the determinants of ectopic fat expansion and dysfunction remains unknown. Here, we focused on the impact of gender in the crosstalk between visceral and epicardial fat depots and the role of adipocytokines and high-sensitivity C-reactive protein (hs-CRP). A total of 141 outward patients (both men and women) with one or more defining criteria for metabolic syndrome (MetS) were consecutively enrolled. For all patients, demographic and clinical data were collected and ultrasound assessment of visceral adipose tissue (VFth) and epicardial fat (EFth) thickness was performed. Hs-CRP and adipocytokine levels were assessed by enzyme-linked immunosorbent assay (ELISA). Men were characterized by increased VFth and EFth (p-value < 0.001 and 0.014, respectively), whereas women showed higher levels of adiponectin and leptin (p-value < 0.001 for both). However, only in women VFth and EFth significantly correlated between them (p = 0.013) and also with leptin (p < 0.001 for both) and hs-CRP (p = 0.005 and p = 0.028, respectively). Linear regression confirmed an independent association of both leptin and hs-CRP with VFth in women, also after adjustment for age and MetS (p = 0.012 and 0.007, respectively). In conclusion, men and women present differences in epicardial fat deposition and systemic inflammation. An intriguing association between visceral/epicardial fat depots and chronic low-grade inflammation also emerged. In women Although a further validation in larger studies is needed, these findings suggest a critical role of sex in stratification of obese/dysmetabolic patients. MDPI 2019-11-27 /pmc/articles/PMC6929041/ /pubmed/31783662 http://dx.doi.org/10.3390/ijms20235981 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Carbone, Federico
Lattanzio, Maria Stefania
Minetti, Silvia
Ansaldo, Anna Maria
Ferrara, Daniele
Molina-Molina, Emilio
Belfiore, Anna
Elia, Edoardo
Pugliese, Stefania
Palmieri, Vincenzo Ostilio
Montecucco, Fabrizio
Portincasa, Piero
Circulating CRP Levels Are Associated with Epicardial and Visceral Fat Depots in Women with Metabolic Syndrome Criteria
title Circulating CRP Levels Are Associated with Epicardial and Visceral Fat Depots in Women with Metabolic Syndrome Criteria
title_full Circulating CRP Levels Are Associated with Epicardial and Visceral Fat Depots in Women with Metabolic Syndrome Criteria
title_fullStr Circulating CRP Levels Are Associated with Epicardial and Visceral Fat Depots in Women with Metabolic Syndrome Criteria
title_full_unstemmed Circulating CRP Levels Are Associated with Epicardial and Visceral Fat Depots in Women with Metabolic Syndrome Criteria
title_short Circulating CRP Levels Are Associated with Epicardial and Visceral Fat Depots in Women with Metabolic Syndrome Criteria
title_sort circulating crp levels are associated with epicardial and visceral fat depots in women with metabolic syndrome criteria
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6929041/
https://www.ncbi.nlm.nih.gov/pubmed/31783662
http://dx.doi.org/10.3390/ijms20235981
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