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Growth Plate Chondrocytes: Skeletal Development, Growth and Beyond
Growth plate chondrocytes play central roles in the proper development and growth of endochondral bones. Particularly, a population of chondrocytes in the resting zone expressing parathyroid hormone-related protein (PTHrP) is now recognized as skeletal stem cells, defined by their ability to undergo...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6929081/ https://www.ncbi.nlm.nih.gov/pubmed/31795305 http://dx.doi.org/10.3390/ijms20236009 |
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author | Hallett, Shawn A. Ono, Wanida Ono, Noriaki |
author_facet | Hallett, Shawn A. Ono, Wanida Ono, Noriaki |
author_sort | Hallett, Shawn A. |
collection | PubMed |
description | Growth plate chondrocytes play central roles in the proper development and growth of endochondral bones. Particularly, a population of chondrocytes in the resting zone expressing parathyroid hormone-related protein (PTHrP) is now recognized as skeletal stem cells, defined by their ability to undergo self-renewal and clonally give rise to columnar chondrocytes in the postnatal growth plate. These chondrocytes also possess the ability to differentiate into a multitude of cell types including osteoblasts and bone marrow stromal cells during skeletal development. Using single-cell transcriptomic approaches and in vivo lineage tracing technology, it is now possible to further elucidate their molecular properties and cellular fate changes. By discovering the fundamental molecular characteristics of these cells, it may be possible to harness their functional characteristics for skeletal growth and regeneration. Here, we discuss our current understanding of the molecular signatures defining growth plate chondrocytes. |
format | Online Article Text |
id | pubmed-6929081 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-69290812019-12-26 Growth Plate Chondrocytes: Skeletal Development, Growth and Beyond Hallett, Shawn A. Ono, Wanida Ono, Noriaki Int J Mol Sci Review Growth plate chondrocytes play central roles in the proper development and growth of endochondral bones. Particularly, a population of chondrocytes in the resting zone expressing parathyroid hormone-related protein (PTHrP) is now recognized as skeletal stem cells, defined by their ability to undergo self-renewal and clonally give rise to columnar chondrocytes in the postnatal growth plate. These chondrocytes also possess the ability to differentiate into a multitude of cell types including osteoblasts and bone marrow stromal cells during skeletal development. Using single-cell transcriptomic approaches and in vivo lineage tracing technology, it is now possible to further elucidate their molecular properties and cellular fate changes. By discovering the fundamental molecular characteristics of these cells, it may be possible to harness their functional characteristics for skeletal growth and regeneration. Here, we discuss our current understanding of the molecular signatures defining growth plate chondrocytes. MDPI 2019-11-29 /pmc/articles/PMC6929081/ /pubmed/31795305 http://dx.doi.org/10.3390/ijms20236009 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Hallett, Shawn A. Ono, Wanida Ono, Noriaki Growth Plate Chondrocytes: Skeletal Development, Growth and Beyond |
title | Growth Plate Chondrocytes: Skeletal Development, Growth and Beyond |
title_full | Growth Plate Chondrocytes: Skeletal Development, Growth and Beyond |
title_fullStr | Growth Plate Chondrocytes: Skeletal Development, Growth and Beyond |
title_full_unstemmed | Growth Plate Chondrocytes: Skeletal Development, Growth and Beyond |
title_short | Growth Plate Chondrocytes: Skeletal Development, Growth and Beyond |
title_sort | growth plate chondrocytes: skeletal development, growth and beyond |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6929081/ https://www.ncbi.nlm.nih.gov/pubmed/31795305 http://dx.doi.org/10.3390/ijms20236009 |
work_keys_str_mv | AT hallettshawna growthplatechondrocytesskeletaldevelopmentgrowthandbeyond AT onowanida growthplatechondrocytesskeletaldevelopmentgrowthandbeyond AT ononoriaki growthplatechondrocytesskeletaldevelopmentgrowthandbeyond |