Pre-Clinical Drug Testing in 2D and 3D Human In Vitro Models of Glioblastoma Incorporating Non-Neoplastic Astrocytes: Tunneling Nano Tubules and Mitochondrial Transfer Modulates Cell Behavior and Therapeutic Respons

The role of astrocytes in the glioblastoma (GBM) microenvironment is poorly understood; particularly with regard to cell invasion and drug resistance. To assess this role of astrocytes in GBMs we established an all human 2D co-culture model and a 3D hyaluronic acid-gelatin based hydrogel model (HySt...

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Detalles Bibliográficos
Autores principales: Civita, Prospero, M. Leite, Diana, Pilkington, Geoffrey J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6929151/
https://www.ncbi.nlm.nih.gov/pubmed/31795330
http://dx.doi.org/10.3390/ijms20236017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6929151/
https://www.ncbi.nlm.nih.gov/pubmed/31795330
http://dx.doi.org/10.3390/ijms20236017

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