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Investigation of somatic CNVs in brains of synucleinopathy cases using targeted SNCA analysis and single cell sequencing

Synucleinopathies are mostly sporadic neurodegenerative disorders of partly unexplained aetiology, and include Parkinson’s disease (PD) and multiple system atrophy (MSA). We have further investigated our recent finding of somatic SNCA (α-synuclein) copy number variants (CNVs, specifically gains) in...

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Detalles Bibliográficos
Autores principales:	Perez-Rodriguez, Diego, Kalyva, Maria, Leija-Salazar, Melissa, Lashley, Tammaryn, Tarabichi, Maxime, Chelban, Viorica, Gentleman, Steve, Schottlaender, Lucia, Franklin, Hannah, Vasmatzis, George, Houlden, Henry, Schapira, Anthony H. V., Warner, Thomas T., Holton, Janice L., Jaunmuktane, Zane, Proukakis, Christos
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6929293/ https://www.ncbi.nlm.nih.gov/pubmed/31870437 http://dx.doi.org/10.1186/s40478-019-0873-5

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