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HTLV-1 infection of myeloid cells: from transmission to immune alterations
Human T cell leukemia virus type 1 (HTLV-1), the etiological agent of adult T-cell leukemia/lymphoma (ATLL) and the demyelinating neuroinflammatory disease known as HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP), was the first human retrovirus to be discovered. T-cells, which re...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6929313/ https://www.ncbi.nlm.nih.gov/pubmed/31870397 http://dx.doi.org/10.1186/s12977-019-0506-x |
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author | Rocamonde, Brenda Carcone, Auriane Mahieux, Renaud Dutartre, Hélène |
author_facet | Rocamonde, Brenda Carcone, Auriane Mahieux, Renaud Dutartre, Hélène |
author_sort | Rocamonde, Brenda |
collection | PubMed |
description | Human T cell leukemia virus type 1 (HTLV-1), the etiological agent of adult T-cell leukemia/lymphoma (ATLL) and the demyelinating neuroinflammatory disease known as HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP), was the first human retrovirus to be discovered. T-cells, which represent the main reservoir for HTLV-1, have been the main focus of studies aimed at understanding viral transmission and disease progression. However, other cell types such as myeloid cells are also target of HTLV-1 infection and display functional alterations as a consequence. In this work, we review the current investigations that shed light on infection, transmission and functional alterations subsequent to HTLV-1 infection of the different myeloid cells types, and we highlight the lack of knowledge in this regard. |
format | Online Article Text |
id | pubmed-6929313 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-69293132019-12-30 HTLV-1 infection of myeloid cells: from transmission to immune alterations Rocamonde, Brenda Carcone, Auriane Mahieux, Renaud Dutartre, Hélène Retrovirology Review Human T cell leukemia virus type 1 (HTLV-1), the etiological agent of adult T-cell leukemia/lymphoma (ATLL) and the demyelinating neuroinflammatory disease known as HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP), was the first human retrovirus to be discovered. T-cells, which represent the main reservoir for HTLV-1, have been the main focus of studies aimed at understanding viral transmission and disease progression. However, other cell types such as myeloid cells are also target of HTLV-1 infection and display functional alterations as a consequence. In this work, we review the current investigations that shed light on infection, transmission and functional alterations subsequent to HTLV-1 infection of the different myeloid cells types, and we highlight the lack of knowledge in this regard. BioMed Central 2019-12-23 /pmc/articles/PMC6929313/ /pubmed/31870397 http://dx.doi.org/10.1186/s12977-019-0506-x Text en © The Author(s) 2019 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Review Rocamonde, Brenda Carcone, Auriane Mahieux, Renaud Dutartre, Hélène HTLV-1 infection of myeloid cells: from transmission to immune alterations |
title | HTLV-1 infection of myeloid cells: from transmission to immune alterations |
title_full | HTLV-1 infection of myeloid cells: from transmission to immune alterations |
title_fullStr | HTLV-1 infection of myeloid cells: from transmission to immune alterations |
title_full_unstemmed | HTLV-1 infection of myeloid cells: from transmission to immune alterations |
title_short | HTLV-1 infection of myeloid cells: from transmission to immune alterations |
title_sort | htlv-1 infection of myeloid cells: from transmission to immune alterations |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6929313/ https://www.ncbi.nlm.nih.gov/pubmed/31870397 http://dx.doi.org/10.1186/s12977-019-0506-x |
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