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Sex hormones affect endothelial lipase-mediated lipid metabolism and atherosclerosis

BACKGROUND: Endothelial lipase (EL) plays an important role in lipoprotein metabolism and atherosclerosis. To study the functional roles of EL, we recently generated transgenic (Tg) rabbits and reported that increased hepatic expression of EL in male Tg rabbits significantly reduced diet-induced hyp...

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Autores principales: Wang, Chuan, Niimi, Manabu, Kitajima, Shuji, Matsuhisa, Fumikazu, Yan, Haizhao, Dong, Sijun, Liang, Jingyan, Fan, Jianglin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6929444/
https://www.ncbi.nlm.nih.gov/pubmed/31870448
http://dx.doi.org/10.1186/s12944-019-1175-4
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author Wang, Chuan
Niimi, Manabu
Kitajima, Shuji
Matsuhisa, Fumikazu
Yan, Haizhao
Dong, Sijun
Liang, Jingyan
Fan, Jianglin
author_facet Wang, Chuan
Niimi, Manabu
Kitajima, Shuji
Matsuhisa, Fumikazu
Yan, Haizhao
Dong, Sijun
Liang, Jingyan
Fan, Jianglin
author_sort Wang, Chuan
collection PubMed
description BACKGROUND: Endothelial lipase (EL) plays an important role in lipoprotein metabolism and atherosclerosis. To study the functional roles of EL, we recently generated transgenic (Tg) rabbits and reported that increased hepatic expression of EL in male Tg rabbits significantly reduced diet-induced hypercholesterolemia compared with non-Tg controls. This gender difference suggests that sex hormones may mediate EL functions thereby influencing lipoprotein metabolism. To examine this hypothesis, we compared the effects of orchiectomy and ovariectomy on plasma lipids and diet-induced atherosclerosis in both Tg and non-Tg rabbits. METHODS: Male rabbits were under orchiectomy whereas female rabbits were under ovariectomy. We compared plasma lipids, lipoproteins, and apolipoproteins of rabbits before and after surgery in each group fed either a chow diet or cholesterol-rich diet. RESULTS: On a chow diet, both male and female Tg rabbits showed lower plasma lipids than non-Tg counterparts and this lipid-lowering effect of EL was not affected by either orchiectomy in male or ovariectomy in female Tg rabbits. On a cholesterol diet; however, male Tg rabbits but not female Tg rabbits showed significant resistance to diet-induced hypercholesterolemia and atherosclerosis. The EL-mediated atheroprotective effect was eliminated after orchiectomy in male Tg rabbits. Female Tg rabbits showed similar levels of total cholesterol and lesion size of atherosclerosis compared with non-Tg rabbits and ovariectomy did not affect diet-induced hypercholesterolemia or atherosclerosis. CONCLUSION: These results suggest that increased EL protects against diet-induced hypercholesterolemia and atherosclerosis. The beneficial effect of EL was dependent upon the presence of androgenic hormones.
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spelling pubmed-69294442019-12-30 Sex hormones affect endothelial lipase-mediated lipid metabolism and atherosclerosis Wang, Chuan Niimi, Manabu Kitajima, Shuji Matsuhisa, Fumikazu Yan, Haizhao Dong, Sijun Liang, Jingyan Fan, Jianglin Lipids Health Dis Research BACKGROUND: Endothelial lipase (EL) plays an important role in lipoprotein metabolism and atherosclerosis. To study the functional roles of EL, we recently generated transgenic (Tg) rabbits and reported that increased hepatic expression of EL in male Tg rabbits significantly reduced diet-induced hypercholesterolemia compared with non-Tg controls. This gender difference suggests that sex hormones may mediate EL functions thereby influencing lipoprotein metabolism. To examine this hypothesis, we compared the effects of orchiectomy and ovariectomy on plasma lipids and diet-induced atherosclerosis in both Tg and non-Tg rabbits. METHODS: Male rabbits were under orchiectomy whereas female rabbits were under ovariectomy. We compared plasma lipids, lipoproteins, and apolipoproteins of rabbits before and after surgery in each group fed either a chow diet or cholesterol-rich diet. RESULTS: On a chow diet, both male and female Tg rabbits showed lower plasma lipids than non-Tg counterparts and this lipid-lowering effect of EL was not affected by either orchiectomy in male or ovariectomy in female Tg rabbits. On a cholesterol diet; however, male Tg rabbits but not female Tg rabbits showed significant resistance to diet-induced hypercholesterolemia and atherosclerosis. The EL-mediated atheroprotective effect was eliminated after orchiectomy in male Tg rabbits. Female Tg rabbits showed similar levels of total cholesterol and lesion size of atherosclerosis compared with non-Tg rabbits and ovariectomy did not affect diet-induced hypercholesterolemia or atherosclerosis. CONCLUSION: These results suggest that increased EL protects against diet-induced hypercholesterolemia and atherosclerosis. The beneficial effect of EL was dependent upon the presence of androgenic hormones. BioMed Central 2019-12-23 /pmc/articles/PMC6929444/ /pubmed/31870448 http://dx.doi.org/10.1186/s12944-019-1175-4 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Wang, Chuan
Niimi, Manabu
Kitajima, Shuji
Matsuhisa, Fumikazu
Yan, Haizhao
Dong, Sijun
Liang, Jingyan
Fan, Jianglin
Sex hormones affect endothelial lipase-mediated lipid metabolism and atherosclerosis
title Sex hormones affect endothelial lipase-mediated lipid metabolism and atherosclerosis
title_full Sex hormones affect endothelial lipase-mediated lipid metabolism and atherosclerosis
title_fullStr Sex hormones affect endothelial lipase-mediated lipid metabolism and atherosclerosis
title_full_unstemmed Sex hormones affect endothelial lipase-mediated lipid metabolism and atherosclerosis
title_short Sex hormones affect endothelial lipase-mediated lipid metabolism and atherosclerosis
title_sort sex hormones affect endothelial lipase-mediated lipid metabolism and atherosclerosis
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6929444/
https://www.ncbi.nlm.nih.gov/pubmed/31870448
http://dx.doi.org/10.1186/s12944-019-1175-4
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