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Inhibition of Nrf2/HO-1 signaling leads to increased activation of the NLRP3 inflammasome in osteoarthritis

INTRODUCTION: Osteoarthritis (OA) is an inflammatory disease of the joints that causes progressive disability in the elderly. Reactive oxygen species (ROS) play an important role in OA development; they may activate the NLRP3 inflammasome, thereby inducing the secretion of proinflammatory IL-1β and...

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Detalles Bibliográficos
Autores principales:	Chen, Zhuming, Zhong, Huan, Wei, Jinsong, Lin, Sien, Zong, Zhixian, Gong, Fan, Huang, Xinqia, Sun, Jinhui, Li, Peng, Lin, Hao, Wei, Bo, Chu, Jiaqi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6929452/ https://www.ncbi.nlm.nih.gov/pubmed/31870428 http://dx.doi.org/10.1186/s13075-019-2085-6

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