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Exploring the association of IL-10 polymorphisms in Behcet’s disease: a systematic review and meta-analysis

BACKGROUND: Polymorphisms in the interleukin-10 (IL-10) gene have been studied in various ethnic groups for possible association with Behçet’s disease (BD). This study aimed to perform a meta-analysis of eligible studies to calculate the association of IL-10 polymorphisms with BD. A systematic liter...

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Autores principales: Shahriyari, Elham, Vahedi, Leila, Roshanipour, Nasrin, Jafarabadi, Mohammad Asghari, Khamaneh, Amin, Laleh, Maryam Ghaffari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6929502/
https://www.ncbi.nlm.nih.gov/pubmed/31889911
http://dx.doi.org/10.1186/s12950-019-0230-2
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author Shahriyari, Elham
Vahedi, Leila
Roshanipour, Nasrin
Jafarabadi, Mohammad Asghari
Khamaneh, Amin
Laleh, Maryam Ghaffari
author_facet Shahriyari, Elham
Vahedi, Leila
Roshanipour, Nasrin
Jafarabadi, Mohammad Asghari
Khamaneh, Amin
Laleh, Maryam Ghaffari
author_sort Shahriyari, Elham
collection PubMed
description BACKGROUND: Polymorphisms in the interleukin-10 (IL-10) gene have been studied in various ethnic groups for possible association with Behçet’s disease (BD). This study aimed to perform a meta-analysis of eligible studies to calculate the association of IL-10 polymorphisms with BD. A systematic literature search was carried out in PubMed, Embase, Web of Science, and Scopus databases to identify relevant publications, and extracted the respective results. Pooled odds ratio (OR) with 95% confidence interval (CI) was used to evaluate the power of association with a random-effects model. RESULTS: A total of 19 articles, consisting of 10,626 patients and 13,592 controls were included in the meta-analysis. The meta-analysis revealed significant associations in allelic and genotypic test models of − 819 (C vs. T: OR = 0.691, P < 0.001; CC vs. TT: OR = 0.466, P < 0.001; CC + CT vs. TT: OR = 0.692, P < 0.001; and CC vs. CT + TT: OR = 0.557, P < 0.001), − 592 (C vs. A: OR = 0.779, P = 0.002; CC + AA vs. AA: OR = 0.713, P = 0.021; and CA vs. AA: OR = 0.716, P = 0.016), rs1518111 (G vs. A: OR = 0.738, P < 0.001; GG vs. AA: OR = 0.570, P < 0.001; GG + AG vs. AA: OR = 0.697, P < 0.001; GG vs. GA + AA: OR = 0.701, P < 0.001; and AG vs. GG: OR = 0.786, P = 0.004) and rs1554286 (C vs. T: OR = 0.582, P < 0.001; CC vs. TT: OR = 0.508, P < 0.001; CC + CT vs. TT: OR = 0.605, P < 0.001; CC vs. CT + TT: OR = 0.665, P = 0.012; and CT vs. TT: OR = 0.646, P = 0.001). However, we failed to find any association between − 1082 polymorphism and susceptibility of BD. CONCLUSION: This meta-analysis demonstrated that the interleukin-10 -819, − 596, rs1518111 and rs1554286 polymorphisms could be responsible against BD susceptibility, and should probably be regarded as a protective factor for Behçet’s disease.
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spelling pubmed-69295022019-12-30 Exploring the association of IL-10 polymorphisms in Behcet’s disease: a systematic review and meta-analysis Shahriyari, Elham Vahedi, Leila Roshanipour, Nasrin Jafarabadi, Mohammad Asghari Khamaneh, Amin Laleh, Maryam Ghaffari J Inflamm (Lond) Research BACKGROUND: Polymorphisms in the interleukin-10 (IL-10) gene have been studied in various ethnic groups for possible association with Behçet’s disease (BD). This study aimed to perform a meta-analysis of eligible studies to calculate the association of IL-10 polymorphisms with BD. A systematic literature search was carried out in PubMed, Embase, Web of Science, and Scopus databases to identify relevant publications, and extracted the respective results. Pooled odds ratio (OR) with 95% confidence interval (CI) was used to evaluate the power of association with a random-effects model. RESULTS: A total of 19 articles, consisting of 10,626 patients and 13,592 controls were included in the meta-analysis. The meta-analysis revealed significant associations in allelic and genotypic test models of − 819 (C vs. T: OR = 0.691, P < 0.001; CC vs. TT: OR = 0.466, P < 0.001; CC + CT vs. TT: OR = 0.692, P < 0.001; and CC vs. CT + TT: OR = 0.557, P < 0.001), − 592 (C vs. A: OR = 0.779, P = 0.002; CC + AA vs. AA: OR = 0.713, P = 0.021; and CA vs. AA: OR = 0.716, P = 0.016), rs1518111 (G vs. A: OR = 0.738, P < 0.001; GG vs. AA: OR = 0.570, P < 0.001; GG + AG vs. AA: OR = 0.697, P < 0.001; GG vs. GA + AA: OR = 0.701, P < 0.001; and AG vs. GG: OR = 0.786, P = 0.004) and rs1554286 (C vs. T: OR = 0.582, P < 0.001; CC vs. TT: OR = 0.508, P < 0.001; CC + CT vs. TT: OR = 0.605, P < 0.001; CC vs. CT + TT: OR = 0.665, P = 0.012; and CT vs. TT: OR = 0.646, P = 0.001). However, we failed to find any association between − 1082 polymorphism and susceptibility of BD. CONCLUSION: This meta-analysis demonstrated that the interleukin-10 -819, − 596, rs1518111 and rs1554286 polymorphisms could be responsible against BD susceptibility, and should probably be regarded as a protective factor for Behçet’s disease. BioMed Central 2019-12-23 /pmc/articles/PMC6929502/ /pubmed/31889911 http://dx.doi.org/10.1186/s12950-019-0230-2 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Shahriyari, Elham
Vahedi, Leila
Roshanipour, Nasrin
Jafarabadi, Mohammad Asghari
Khamaneh, Amin
Laleh, Maryam Ghaffari
Exploring the association of IL-10 polymorphisms in Behcet’s disease: a systematic review and meta-analysis
title Exploring the association of IL-10 polymorphisms in Behcet’s disease: a systematic review and meta-analysis
title_full Exploring the association of IL-10 polymorphisms in Behcet’s disease: a systematic review and meta-analysis
title_fullStr Exploring the association of IL-10 polymorphisms in Behcet’s disease: a systematic review and meta-analysis
title_full_unstemmed Exploring the association of IL-10 polymorphisms in Behcet’s disease: a systematic review and meta-analysis
title_short Exploring the association of IL-10 polymorphisms in Behcet’s disease: a systematic review and meta-analysis
title_sort exploring the association of il-10 polymorphisms in behcet’s disease: a systematic review and meta-analysis
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6929502/
https://www.ncbi.nlm.nih.gov/pubmed/31889911
http://dx.doi.org/10.1186/s12950-019-0230-2
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