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Residential distance from high-voltage overhead power lines and risk of Alzheimer’s dementia and Parkinson’s disease: a population-based case-control study in a metropolitan area of Northern Italy

BACKGROUND: The association between the extremely low-frequency magnetic field generated by overhead power lines and neurodegenerative disease is still a matter of debate. METHODS: A population-based case-control study was carried out on the residents in the Milan metropolitan area between 2011 and...

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Autores principales: Gervasi, Federico, Murtas, Rossella, Decarli, Adriano, Russo, Antonio Giampiero
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6929536/
https://www.ncbi.nlm.nih.gov/pubmed/31280302
http://dx.doi.org/10.1093/ije/dyz139
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author Gervasi, Federico
Murtas, Rossella
Decarli, Adriano
Russo, Antonio Giampiero
author_facet Gervasi, Federico
Murtas, Rossella
Decarli, Adriano
Russo, Antonio Giampiero
author_sort Gervasi, Federico
collection PubMed
description BACKGROUND: The association between the extremely low-frequency magnetic field generated by overhead power lines and neurodegenerative disease is still a matter of debate. METHODS: A population-based case-control study was carried out on the residents in the Milan metropolitan area between 2011 and 2016 to evaluate the possible association between exposure to extremely low-frequency magnetic fields generated by high-voltage overhead power lines and Alzheimer's dementia and Parkinson's disease. A statistical analysis was performed on cases and controls matched by sex, year of birth and municipality of residence (with a case to controls ratio of 1 : 4) using conditional logistic regression models adjusted for socio-economic deprivation and distance from the major road network as potential confounders. RESULTS: Odds ratios for residents <50 m from the source of exposure compared with residents at ≥600 m turned out to be 1.11 (95% confidence interval: 0.95–1.30) for Alzheimer's dementia and 1.09 (95% confidence interval: 0.92–1.30) for Parkinson's disease. CONCLUSIONS: The finding of a weak association between exposure to the extremely low-frequency magnetic field and neurodegenerative diseases suggests the continuation of research on this topic. Moreover, the low consistency between the results of the already existing studies emphasises the importance of increasingly refined study designs.
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spelling pubmed-69295362019-12-30 Residential distance from high-voltage overhead power lines and risk of Alzheimer’s dementia and Parkinson’s disease: a population-based case-control study in a metropolitan area of Northern Italy Gervasi, Federico Murtas, Rossella Decarli, Adriano Russo, Antonio Giampiero Int J Epidemiol Ageing and Dementia BACKGROUND: The association between the extremely low-frequency magnetic field generated by overhead power lines and neurodegenerative disease is still a matter of debate. METHODS: A population-based case-control study was carried out on the residents in the Milan metropolitan area between 2011 and 2016 to evaluate the possible association between exposure to extremely low-frequency magnetic fields generated by high-voltage overhead power lines and Alzheimer's dementia and Parkinson's disease. A statistical analysis was performed on cases and controls matched by sex, year of birth and municipality of residence (with a case to controls ratio of 1 : 4) using conditional logistic regression models adjusted for socio-economic deprivation and distance from the major road network as potential confounders. RESULTS: Odds ratios for residents <50 m from the source of exposure compared with residents at ≥600 m turned out to be 1.11 (95% confidence interval: 0.95–1.30) for Alzheimer's dementia and 1.09 (95% confidence interval: 0.92–1.30) for Parkinson's disease. CONCLUSIONS: The finding of a weak association between exposure to the extremely low-frequency magnetic field and neurodegenerative diseases suggests the continuation of research on this topic. Moreover, the low consistency between the results of the already existing studies emphasises the importance of increasingly refined study designs. Oxford University Press 2019-12 2019-07-06 /pmc/articles/PMC6929536/ /pubmed/31280302 http://dx.doi.org/10.1093/ije/dyz139 Text en © The Author(s) 2019. Published by Oxford University Press on behalf of the International Epidemiological Association. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Ageing and Dementia
Gervasi, Federico
Murtas, Rossella
Decarli, Adriano
Russo, Antonio Giampiero
Residential distance from high-voltage overhead power lines and risk of Alzheimer’s dementia and Parkinson’s disease: a population-based case-control study in a metropolitan area of Northern Italy
title Residential distance from high-voltage overhead power lines and risk of Alzheimer’s dementia and Parkinson’s disease: a population-based case-control study in a metropolitan area of Northern Italy
title_full Residential distance from high-voltage overhead power lines and risk of Alzheimer’s dementia and Parkinson’s disease: a population-based case-control study in a metropolitan area of Northern Italy
title_fullStr Residential distance from high-voltage overhead power lines and risk of Alzheimer’s dementia and Parkinson’s disease: a population-based case-control study in a metropolitan area of Northern Italy
title_full_unstemmed Residential distance from high-voltage overhead power lines and risk of Alzheimer’s dementia and Parkinson’s disease: a population-based case-control study in a metropolitan area of Northern Italy
title_short Residential distance from high-voltage overhead power lines and risk of Alzheimer’s dementia and Parkinson’s disease: a population-based case-control study in a metropolitan area of Northern Italy
title_sort residential distance from high-voltage overhead power lines and risk of alzheimer’s dementia and parkinson’s disease: a population-based case-control study in a metropolitan area of northern italy
topic Ageing and Dementia
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6929536/
https://www.ncbi.nlm.nih.gov/pubmed/31280302
http://dx.doi.org/10.1093/ije/dyz139
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