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Implementing Efficient Peptoid‐Mediated Delivery of RNA‐Based Therapeutics to the Vocal Folds

OBJECTIVE: We hypothesize that Smad3 is a master regulator of fibrosis in the vocal folds (VFs) and RNA‐based therapeutics targeting Smad3 hold therapeutic promise. Delivery remains challenging. We previously described a novel synthetic peptoid oligomer, lipitoid L0, complexed with siRNA to improve...

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Detalles Bibliográficos
Autores principales:	Mukudai, Shigeyuki, Kraja, Iv, Bing, Renjie, Nalband, Danielle M., Tatikola, Mallika, Hiwatashi, Nao, Kirshenbaum, Kent, Branski, Ryan C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Inc. 2019
Materias:	LARYNGOLOGY, SPEECH AND LANGUAGE SCIENCE
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6929602/ https://www.ncbi.nlm.nih.gov/pubmed/31890882 http://dx.doi.org/10.1002/lio2.310

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