Cargando…

Characteristics of patients with systemic sclerosis living in Qatar

Objective: The aim of this study was to determine the demographic, clinical, and immunological characteristics of patients with systemic sclerosis living in Qatar. Method: This retrospective study included 42 patients with systemic sclerosis who attended Rheumatology Clinics at Hamad General Hospita...

Descripción completa

Detalles Bibliográficos
Autores principales: Alam, Fiaz, Abdulaziz, Hani Malallah, Ul Haq, Irfan, Mahdy, Salah Mohamed, Mohammed Siam, Abdul Rahim, Chandra, Prem, Al Emadi, Samar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: HBKU Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6929649/
https://www.ncbi.nlm.nih.gov/pubmed/31903322
http://dx.doi.org/10.5339/qmj.2019.16
_version_ 1783482744534204416
author Alam, Fiaz
Abdulaziz, Hani Malallah
Ul Haq, Irfan
Mahdy, Salah Mohamed
Mohammed Siam, Abdul Rahim
Chandra, Prem
Al Emadi, Samar
author_facet Alam, Fiaz
Abdulaziz, Hani Malallah
Ul Haq, Irfan
Mahdy, Salah Mohamed
Mohammed Siam, Abdul Rahim
Chandra, Prem
Al Emadi, Samar
author_sort Alam, Fiaz
collection PubMed
description Objective: The aim of this study was to determine the demographic, clinical, and immunological characteristics of patients with systemic sclerosis living in Qatar. Method: This retrospective study included 42 patients with systemic sclerosis who attended Rheumatology Clinics at Hamad General Hospital in Doha, Qatar, between January 2000 and December 2014. All patients fulfilled the 1980 American College of Rheumatology (ACR) classification criteria for systemic sclerosis. Results: The 42 consecutively recruited patients of mixed ethnicities consisted of 37 (88.1%) females and 5 (11.9%) males. Of the total 42 patients, 22 (52.4%) had diffuse cutaneous systemic sclerosis (dcSSc) and 20 (47.6%) had limited cutaneous systemic sclerosis (lcSSc). Mean age at onset of first symptoms was 34.5 ± 12 years, and mean age at diagnosis was 36.1 ± 11.5 years. During follow-up, Raynaud's phenomenon occurred in 36 (85.7%) patients, sclerodactyly in 39 (92.9%) patients, digital ulcers in 16 (38.1%) patients, calcinosis in 6 (14.3%) patients, telangiectasia in 16 (38.1%) patients, and arthritis in 13 (31%) patients. The gastrointestinal and respiratory systems were the most frequently affected internal organs. Gastrointestinal involvement was present in 36 (85.7%) patients, and respiratory involvement was found in 30 (71.4%) patients. The majority of patients had positive antinuclear antibodies (ANA; 97.6%). Anti-Scl-70 antibody was found in 66.7% and anti-centromere antibody (ACA) was detected in 14.3% of the patients. Conclusion: To our knowledge, this is the first study that describes the clinical and immunological profile of patients with systemic sclerosis living in Qatar. This study cohort showed an earlier age of disease onset and diagnosis than that reported in other international studies. Furthermore, in contrast to several other studies, the diffuse type of scleroderma was more commonly observed than the limited type, which resulted in a high frequency of anti-Scl-70 antibody and interstitial lung disease.
format Online
Article
Text
id pubmed-6929649
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher HBKU Press
record_format MEDLINE/PubMed
spelling pubmed-69296492020-01-03 Characteristics of patients with systemic sclerosis living in Qatar Alam, Fiaz Abdulaziz, Hani Malallah Ul Haq, Irfan Mahdy, Salah Mohamed Mohammed Siam, Abdul Rahim Chandra, Prem Al Emadi, Samar Qatar Med J Research Article Objective: The aim of this study was to determine the demographic, clinical, and immunological characteristics of patients with systemic sclerosis living in Qatar. Method: This retrospective study included 42 patients with systemic sclerosis who attended Rheumatology Clinics at Hamad General Hospital in Doha, Qatar, between January 2000 and December 2014. All patients fulfilled the 1980 American College of Rheumatology (ACR) classification criteria for systemic sclerosis. Results: The 42 consecutively recruited patients of mixed ethnicities consisted of 37 (88.1%) females and 5 (11.9%) males. Of the total 42 patients, 22 (52.4%) had diffuse cutaneous systemic sclerosis (dcSSc) and 20 (47.6%) had limited cutaneous systemic sclerosis (lcSSc). Mean age at onset of first symptoms was 34.5 ± 12 years, and mean age at diagnosis was 36.1 ± 11.5 years. During follow-up, Raynaud's phenomenon occurred in 36 (85.7%) patients, sclerodactyly in 39 (92.9%) patients, digital ulcers in 16 (38.1%) patients, calcinosis in 6 (14.3%) patients, telangiectasia in 16 (38.1%) patients, and arthritis in 13 (31%) patients. The gastrointestinal and respiratory systems were the most frequently affected internal organs. Gastrointestinal involvement was present in 36 (85.7%) patients, and respiratory involvement was found in 30 (71.4%) patients. The majority of patients had positive antinuclear antibodies (ANA; 97.6%). Anti-Scl-70 antibody was found in 66.7% and anti-centromere antibody (ACA) was detected in 14.3% of the patients. Conclusion: To our knowledge, this is the first study that describes the clinical and immunological profile of patients with systemic sclerosis living in Qatar. This study cohort showed an earlier age of disease onset and diagnosis than that reported in other international studies. Furthermore, in contrast to several other studies, the diffuse type of scleroderma was more commonly observed than the limited type, which resulted in a high frequency of anti-Scl-70 antibody and interstitial lung disease. HBKU Press 2019-12-24 /pmc/articles/PMC6929649/ /pubmed/31903322 http://dx.doi.org/10.5339/qmj.2019.16 Text en © 2019 Alam, Abdulaziz, Ul Haq, Mahdy, Mohammed Siam, Chandra, Al Emadi, licensee HBKU Press. This is an open access article distributed under the terms of the Creative Commons Attribution license CC BY 4.0, which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Alam, Fiaz
Abdulaziz, Hani Malallah
Ul Haq, Irfan
Mahdy, Salah Mohamed
Mohammed Siam, Abdul Rahim
Chandra, Prem
Al Emadi, Samar
Characteristics of patients with systemic sclerosis living in Qatar
title Characteristics of patients with systemic sclerosis living in Qatar
title_full Characteristics of patients with systemic sclerosis living in Qatar
title_fullStr Characteristics of patients with systemic sclerosis living in Qatar
title_full_unstemmed Characteristics of patients with systemic sclerosis living in Qatar
title_short Characteristics of patients with systemic sclerosis living in Qatar
title_sort characteristics of patients with systemic sclerosis living in qatar
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6929649/
https://www.ncbi.nlm.nih.gov/pubmed/31903322
http://dx.doi.org/10.5339/qmj.2019.16
work_keys_str_mv AT alamfiaz characteristicsofpatientswithsystemicsclerosislivinginqatar
AT abdulazizhanimalallah characteristicsofpatientswithsystemicsclerosislivinginqatar
AT ulhaqirfan characteristicsofpatientswithsystemicsclerosislivinginqatar
AT mahdysalahmohamed characteristicsofpatientswithsystemicsclerosislivinginqatar
AT mohammedsiamabdulrahim characteristicsofpatientswithsystemicsclerosislivinginqatar
AT chandraprem characteristicsofpatientswithsystemicsclerosislivinginqatar
AT alemadisamar characteristicsofpatientswithsystemicsclerosislivinginqatar