PI3Kα in cardioprotection: Cytoskeleton, late Na(+) current, and mechanism of arrhythmias

PI 3-kinase α (PI3Kα) is a lipid kinase that converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-triphosphate (PIP3). PI3Kα regulates a variety of cellular processes such as nutrient sensing, cell cycle, migration, and others. Heightened activity of PI3Kα in many type...

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Detalles Bibliográficos
Autores principales: Zhabyeyev, Pavel, Chen, Xueyi, Vanhaesebroeck, Bart, Oudit, Gavin Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930018/
https://www.ncbi.nlm.nih.gov/pubmed/31790629
http://dx.doi.org/10.1080/19336950.2019.1697127
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author Zhabyeyev, Pavel
Chen, Xueyi
Vanhaesebroeck, Bart
Oudit, Gavin Y.
author_facet Zhabyeyev, Pavel
Chen, Xueyi
Vanhaesebroeck, Bart
Oudit, Gavin Y.
author_sort Zhabyeyev, Pavel
collection PubMed
description PI 3-kinase α (PI3Kα) is a lipid kinase that converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-triphosphate (PIP3). PI3Kα regulates a variety of cellular processes such as nutrient sensing, cell cycle, migration, and others. Heightened activity of PI3Kα in many types of cancer made it a prime oncology drug target, but also raises concerns of possible adverse effects on the heart. Indeed, recent advances in preclinical models demonstrate an important role of PI3Kα in the control of cytoskeletal integrity, Na(+) channel activity, cardioprotection, and prevention of arrhythmias.
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spelling pubmed-69300182020-01-03 PI3Kα in cardioprotection: Cytoskeleton, late Na(+) current, and mechanism of arrhythmias Zhabyeyev, Pavel Chen, Xueyi Vanhaesebroeck, Bart Oudit, Gavin Y. Channels (Austin) Review PI 3-kinase α (PI3Kα) is a lipid kinase that converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-triphosphate (PIP3). PI3Kα regulates a variety of cellular processes such as nutrient sensing, cell cycle, migration, and others. Heightened activity of PI3Kα in many types of cancer made it a prime oncology drug target, but also raises concerns of possible adverse effects on the heart. Indeed, recent advances in preclinical models demonstrate an important role of PI3Kα in the control of cytoskeletal integrity, Na(+) channel activity, cardioprotection, and prevention of arrhythmias. Taylor & Francis 2019-12-02 /pmc/articles/PMC6930018/ /pubmed/31790629 http://dx.doi.org/10.1080/19336950.2019.1697127 Text en © 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Zhabyeyev, Pavel
Chen, Xueyi
Vanhaesebroeck, Bart
Oudit, Gavin Y.
PI3Kα in cardioprotection: Cytoskeleton, late Na(+) current, and mechanism of arrhythmias
title PI3Kα in cardioprotection: Cytoskeleton, late Na(+) current, and mechanism of arrhythmias
title_full PI3Kα in cardioprotection: Cytoskeleton, late Na(+) current, and mechanism of arrhythmias
title_fullStr PI3Kα in cardioprotection: Cytoskeleton, late Na(+) current, and mechanism of arrhythmias
title_full_unstemmed PI3Kα in cardioprotection: Cytoskeleton, late Na(+) current, and mechanism of arrhythmias
title_short PI3Kα in cardioprotection: Cytoskeleton, late Na(+) current, and mechanism of arrhythmias
title_sort pi3kα in cardioprotection: cytoskeleton, late na(+) current, and mechanism of arrhythmias
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930018/
https://www.ncbi.nlm.nih.gov/pubmed/31790629
http://dx.doi.org/10.1080/19336950.2019.1697127
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AT vanhaesebroeckbart pi3kaincardioprotectioncytoskeletonlatenacurrentandmechanismofarrhythmias
AT ouditgaviny pi3kaincardioprotectioncytoskeletonlatenacurrentandmechanismofarrhythmias

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