Cargando…

Subcellular drug targeting illuminates local kinase action

Deciphering how signaling enzymes operate within discrete microenvironments is fundamental to understanding biological processes. A-kinase anchoring proteins (AKAPs) restrict the range of action of protein kinases within intracellular compartments. We exploited the AKAP targeting concept to create g...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bucko, Paula J, Lombard, Chloe K, Rathbun, Lindsay, Garcia, Irvin, Bhat, Akansha, Wordeman, Linda, Smith, F Donelson, Maly, Dustin J, Hehnly, Heidi, Scott, John D
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2019
Materias:	Biochemistry and Chemical Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930117/ https://www.ncbi.nlm.nih.gov/pubmed/31872801 http://dx.doi.org/10.7554/eLife.52220

Ejemplares similares

A mitotic kinase scaffold depleted in testicular seminomas impacts spindle orientation in germ line stem cells
por: Hehnly, Heidi, et al.
Publicado: (2015)

A subcellular map of the human kinome
por: Zhang, Haitao, et al.
Publicado: (2021)

Puromycin reactivity does not accurately localize translation at the subcellular level
por: Enam, Syed Usman, et al.
Publicado: (2020)

An acquired scaffolding function of the DNAJ-PKAc fusion contributes to oncogenic signaling in fibrolamellar carcinoma
por: Turnham, Rigney E, et al.
Publicado: (2019)

Light-regulated allosteric switch enables temporal and subcellular control of enzyme activity
por: Shaaya, Mark, et al.
Publicado: (2020)

Mechanisms of PDZ domain scaffold assembly illuminated by use of supported cell membrane sheets
por: Erlendsson, Simon, et al.
Publicado: (2019)

Post-translational regulation of retinal IMPDH1 in vivo to adjust GTP synthesis to illumination conditions
por: Plana-Bonamaisó, Anna, et al.
Publicado: (2020)

A coarse-grained NADH redox model enables inference of subcellular metabolic fluxes from fluorescence lifetime imaging
por: Yang, Xingbo, et al.
Publicado: (2021)

Intrinsic disorder within an AKAP-protein kinase A complex guides local substrate phosphorylation
por: Smith, F Donelson, et al.
Publicado: (2013)

Complex effects of kinase localization revealed by compartment-specific regulation of protein kinase A activity
por: LaCroix, Rebecca, et al.
Publicado: (2022)

Illuminating the druggable genome through patent bioactivity data
por: Magariños, Maria P., et al.
Publicado: (2023)

Probing conformational dynamics to understand kinase inhibition
por: Outhwaite, Ian R, et al.
Publicado: (2023)

Allosteric regulation of kinase activity in living cells
por: Godbole, Shivani Sujay, et al.
Publicado: (2023)

Towards novel herbicide modes of action by inhibiting lysine biosynthesis in plants
por: Soares da Costa, Tatiana P, et al.
Publicado: (2021)

Breakage of the oligomeric CaMKII hub by the regulatory segment of the kinase
por: Karandur, Deepti, et al.
Publicado: (2020)

Autoregulatory control of microtubule binding in doublecortin-like kinase 1
por: Agulto, Regina L, et al.
Publicado: (2021)

Cyclin-dependent kinase 5 (CDK5) regulates the circadian clock
por: Brenna, Andrea, et al.
Publicado: (2019)

An auto-inhibited state of protein kinase G and implications for selective activation
por: Sharma, Rajesh, et al.
Publicado: (2022)

An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor
por: Aguirre, Tim, et al.
Publicado: (2023)

A critical evaluation of protein kinase regulation by activation loop autophosphorylation
por: Reinhardt, Ronja, et al.
Publicado: (2023)

The structural basis of the multi-step allosteric activation of Aurora B kinase
por: Segura-Peña, Dario, et al.
Publicado: (2023)

Uncovering an allosteric mode of action for a selective inhibitor of human Bloom syndrome protein
por: Chen, Xiangrong, et al.
Publicado: (2021)

Two bifunctional inositol pyrophosphate kinases/phosphatases control plant phosphate homeostasis
por: Zhu, Jinsheng, et al.
Publicado: (2019)

AKAP79 enables calcineurin to directly suppress protein kinase A activity
por: Church, Timothy W, et al.
Publicado: (2021)

Membrane-mediated dimerization potentiates PIP5K lipid kinase activity
por: Hansen, Scott D, et al.
Publicado: (2022)

Stimulation of the catalytic activity of the tyrosine kinase Btk by the adaptor protein Grb2
por: Nocka, Laura M, et al.
Publicado: (2023)

A back-door insight into the modulation of Src kinase activity by the polyamine spermidine
por: Rossini, Sofia, et al.
Publicado: (2023)

The NTP generating activity of pyruvate kinase II is critical for apicoplast maintenance in Plasmodium falciparum
por: Swift, Russell P, et al.
Publicado: (2020)

Allosteric mechanism of signal transduction in the two-component system histidine kinase PhoQ
por: Mensa, Bruk, et al.
Publicado: (2021)

The orphan ligand, activin C, signals through activin receptor-like kinase 7
por: Goebel, Erich J, et al.
Publicado: (2022)

A feed-forward pathway drives LRRK2 kinase membrane recruitment and activation
por: Vides, Edmundo G, et al.
Publicado: (2022)

The Axin scaffold protects the kinase GSK3β from cross-pathway inhibition
por: Gavagan, Maire, et al.
Publicado: (2023)

Structural insight into guanylyl cyclase receptor hijacking of the kinase–Hsp90 regulatory mechanism
por: Caveney, Nathanael A, et al.
Publicado: (2023)

Crosstalk between repair pathways elicits double-strand breaks in alkylated DNA and implications for the action of temozolomide
por: Fuchs, Robert P, et al.
Publicado: (2021)

McsB forms a gated kinase chamber to mark aberrant bacterial proteins for degradation
por: Hajdusits, Bence, et al.
Publicado: (2021)

Reciprocal regulation among TRPV1 channels and phosphoinositide 3-kinase in response to nerve growth factor
por: Stratiievska, Anastasiia, et al.
Publicado: (2018)

Phosphorylation of tyrosine 90 in SH3 domain is a new regulatory switch controlling Src kinase
por: Koudelková, Lenka, et al.
Publicado: (2023)

A secretory pathway kinase regulates sarcoplasmic reticulum Ca(2+) homeostasis and protects against heart failure
por: Pollak, Adam J, et al.
Publicado: (2018)

A Fyn biosensor reveals pulsatile, spatially localized kinase activity and signaling crosstalk in live mammalian cells
por: Mukherjee, Ananya, et al.
Publicado: (2020)

High-throughput profiling of sequence recognition by tyrosine kinases and SH2 domains using bacterial peptide display
por: Li, Allyson, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_g9srelafre90npot92ukifedks