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Metabolic heterogeneity confers differences in melanoma metastatic potential

Metastasis requires cancer cells to undergo poorly-understood metabolic changes(1–3). We found that metabolic differences among melanoma cells confer differences in metastatic potential as a result of differences in Monocarboxylate Transporter 1 (MCT1) function. In vivo isotope tracing in patient-de...

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Detalles Bibliográficos
Autores principales:	Tasdogan, Alpaslan, Faubert, Brandon, Ramesh, Vijayashree, Ubellacker, Jessalyn M., Shen, Bo, Solmonson, Ashley, Murphy, Malea M., Gu, Zhimin, Gu, Wen, Martin, Misty, Kasitinon, Stacy Y., Vandergriff, Travis, Mathews, Thomas P., Zhao, Zhiyu, Schadendorf, Dirk, DeBerardinis, Ralph J., Morrison, Sean J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930341/ https://www.ncbi.nlm.nih.gov/pubmed/31853067 http://dx.doi.org/10.1038/s41586-019-1847-2

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