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A Long Non-coding RNA Lnc712 Regulates Breast Cancer Cell Proliferation

Great quantity of intergenic noncoding RNAs (lncRNAs) have been identified in the mammalian genome and involved in various biological processes, especially in the development and metastasis of cancer. In this study, we identified one lncRNA, lncRNA NONHSAT028712 (Lnc712), was highly expressed in bre...

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Autores principales: Cui, Yue, Lu, Chunxiao, Zhang, Zhiming, Mao, Aiqin, Feng, Lei, Fu, Li, Gu, Feng, Ma, Xin, He, Dongxu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930380/
https://www.ncbi.nlm.nih.gov/pubmed/31892853
http://dx.doi.org/10.7150/ijbs.36429
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author Cui, Yue
Lu, Chunxiao
Zhang, Zhiming
Mao, Aiqin
Feng, Lei
Fu, Li
Gu, Feng
Ma, Xin
He, Dongxu
author_facet Cui, Yue
Lu, Chunxiao
Zhang, Zhiming
Mao, Aiqin
Feng, Lei
Fu, Li
Gu, Feng
Ma, Xin
He, Dongxu
author_sort Cui, Yue
collection PubMed
description Great quantity of intergenic noncoding RNAs (lncRNAs) have been identified in the mammalian genome and involved in various biological processes, especially in the development and metastasis of cancer. In this study, we identified one lncRNA, lncRNA NONHSAT028712 (Lnc712), was highly expressed in breast cancer cell lines and tissues based on microarray screening. Knockdown of Lnc712 largely inhibited breast cancer cell proliferation. Mechanistically, Lnc712 bound specifically to heat-shock protein 90 (HSP90). Interaction between Lnc712 and HSP90 is required for HSP90 binding to cell division cycle 37 (Cdc37). The Lnc712/HSP90/Cdc37 complex regulated cyclin-dependent kinase 2 (CDK2) activation and then triggered breast cancer cell proliferation. In summary, our results identified a new lncRNA regulate breast cancer proliferation though interaction with HSP90.
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spelling pubmed-69303802020-01-01 A Long Non-coding RNA Lnc712 Regulates Breast Cancer Cell Proliferation Cui, Yue Lu, Chunxiao Zhang, Zhiming Mao, Aiqin Feng, Lei Fu, Li Gu, Feng Ma, Xin He, Dongxu Int J Biol Sci Research Paper Great quantity of intergenic noncoding RNAs (lncRNAs) have been identified in the mammalian genome and involved in various biological processes, especially in the development and metastasis of cancer. In this study, we identified one lncRNA, lncRNA NONHSAT028712 (Lnc712), was highly expressed in breast cancer cell lines and tissues based on microarray screening. Knockdown of Lnc712 largely inhibited breast cancer cell proliferation. Mechanistically, Lnc712 bound specifically to heat-shock protein 90 (HSP90). Interaction between Lnc712 and HSP90 is required for HSP90 binding to cell division cycle 37 (Cdc37). The Lnc712/HSP90/Cdc37 complex regulated cyclin-dependent kinase 2 (CDK2) activation and then triggered breast cancer cell proliferation. In summary, our results identified a new lncRNA regulate breast cancer proliferation though interaction with HSP90. Ivyspring International Publisher 2020-01-01 /pmc/articles/PMC6930380/ /pubmed/31892853 http://dx.doi.org/10.7150/ijbs.36429 Text en © The author(s) This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Cui, Yue
Lu, Chunxiao
Zhang, Zhiming
Mao, Aiqin
Feng, Lei
Fu, Li
Gu, Feng
Ma, Xin
He, Dongxu
A Long Non-coding RNA Lnc712 Regulates Breast Cancer Cell Proliferation
title A Long Non-coding RNA Lnc712 Regulates Breast Cancer Cell Proliferation
title_full A Long Non-coding RNA Lnc712 Regulates Breast Cancer Cell Proliferation
title_fullStr A Long Non-coding RNA Lnc712 Regulates Breast Cancer Cell Proliferation
title_full_unstemmed A Long Non-coding RNA Lnc712 Regulates Breast Cancer Cell Proliferation
title_short A Long Non-coding RNA Lnc712 Regulates Breast Cancer Cell Proliferation
title_sort long non-coding rna lnc712 regulates breast cancer cell proliferation
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930380/
https://www.ncbi.nlm.nih.gov/pubmed/31892853
http://dx.doi.org/10.7150/ijbs.36429
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