Cargando…
High expression levels of TLR9 and PD-L1 indicates a poor prognosis in patients with angioimmunoblastic T-cell lymphoma: a retrospective study of 88 cases in a single center
Background: The role of TLR9 expressed by tumor cells in evading immune surveillance was confirmed. PD-L1 expression in tumor cells plays a key role in tumor immune escape, which is associated with poor prognosis. However, the clinical relevance of TLR9 and PD-L1 expression in angioimmunoblastic T-c...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930404/ https://www.ncbi.nlm.nih.gov/pubmed/31892973 http://dx.doi.org/10.7150/jca.37033 |
_version_ | 1783482883834380288 |
---|---|
author | Qian, Jingrong Meng, Hongxue Lv, Bowen Wang, Jie Lu, Yingying Su, Liju Zhao, Shu Li, Wenhui |
author_facet | Qian, Jingrong Meng, Hongxue Lv, Bowen Wang, Jie Lu, Yingying Su, Liju Zhao, Shu Li, Wenhui |
author_sort | Qian, Jingrong |
collection | PubMed |
description | Background: The role of TLR9 expressed by tumor cells in evading immune surveillance was confirmed. PD-L1 expression in tumor cells plays a key role in tumor immune escape, which is associated with poor prognosis. However, the clinical relevance of TLR9 and PD-L1 expression in angioimmunoblastic T-cell lymphoma (AITL) has not been evaluated. Materials and methods: In this study, we identified differentially expressed genes in AITL samples by bioinformatic analysis, and we first examined TLR9 and PD-L1 expression by immunohistochemical staining in patients with AITL and compared these data with clinical features and survival time. Results: It was found that the expression of PD-L1 and multiple TLRs was higher in AITL than normal T-cell samples, and TLR9 and PD-L1 expression displayed complex interactions by bioinformatic analysis. The rates of TLR9 and PD-L1 high expression were 69% and 50%, respectively. High expression of either TLR9 or PD-L1 indicated a poor survival rate for patients with AITL. Multivariate analysis further confirmed that high expression levels of TLR9 and PD-L1 were unfavorable prognostic factors for AITL. We further found inferior overall survival in AITL with clinical features of ECOG status ≥ 2, advanced-stage, elevated serum LDH levels, elevated serum β(2)-MG levels, and high IPI score. Conclusion: TLR9 and PD-L1 expression may be a novel predictor of prognosis for patients with AITL and may serve as potential therapeutic strategy. |
format | Online Article Text |
id | pubmed-6930404 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Ivyspring International Publisher |
record_format | MEDLINE/PubMed |
spelling | pubmed-69304042020-01-01 High expression levels of TLR9 and PD-L1 indicates a poor prognosis in patients with angioimmunoblastic T-cell lymphoma: a retrospective study of 88 cases in a single center Qian, Jingrong Meng, Hongxue Lv, Bowen Wang, Jie Lu, Yingying Su, Liju Zhao, Shu Li, Wenhui J Cancer Research Paper Background: The role of TLR9 expressed by tumor cells in evading immune surveillance was confirmed. PD-L1 expression in tumor cells plays a key role in tumor immune escape, which is associated with poor prognosis. However, the clinical relevance of TLR9 and PD-L1 expression in angioimmunoblastic T-cell lymphoma (AITL) has not been evaluated. Materials and methods: In this study, we identified differentially expressed genes in AITL samples by bioinformatic analysis, and we first examined TLR9 and PD-L1 expression by immunohistochemical staining in patients with AITL and compared these data with clinical features and survival time. Results: It was found that the expression of PD-L1 and multiple TLRs was higher in AITL than normal T-cell samples, and TLR9 and PD-L1 expression displayed complex interactions by bioinformatic analysis. The rates of TLR9 and PD-L1 high expression were 69% and 50%, respectively. High expression of either TLR9 or PD-L1 indicated a poor survival rate for patients with AITL. Multivariate analysis further confirmed that high expression levels of TLR9 and PD-L1 were unfavorable prognostic factors for AITL. We further found inferior overall survival in AITL with clinical features of ECOG status ≥ 2, advanced-stage, elevated serum LDH levels, elevated serum β(2)-MG levels, and high IPI score. Conclusion: TLR9 and PD-L1 expression may be a novel predictor of prognosis for patients with AITL and may serve as potential therapeutic strategy. Ivyspring International Publisher 2020-01-01 /pmc/articles/PMC6930404/ /pubmed/31892973 http://dx.doi.org/10.7150/jca.37033 Text en © The author(s) This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions. |
spellingShingle | Research Paper Qian, Jingrong Meng, Hongxue Lv, Bowen Wang, Jie Lu, Yingying Su, Liju Zhao, Shu Li, Wenhui High expression levels of TLR9 and PD-L1 indicates a poor prognosis in patients with angioimmunoblastic T-cell lymphoma: a retrospective study of 88 cases in a single center |
title | High expression levels of TLR9 and PD-L1 indicates a poor prognosis in patients with angioimmunoblastic T-cell lymphoma: a retrospective study of 88 cases in a single center |
title_full | High expression levels of TLR9 and PD-L1 indicates a poor prognosis in patients with angioimmunoblastic T-cell lymphoma: a retrospective study of 88 cases in a single center |
title_fullStr | High expression levels of TLR9 and PD-L1 indicates a poor prognosis in patients with angioimmunoblastic T-cell lymphoma: a retrospective study of 88 cases in a single center |
title_full_unstemmed | High expression levels of TLR9 and PD-L1 indicates a poor prognosis in patients with angioimmunoblastic T-cell lymphoma: a retrospective study of 88 cases in a single center |
title_short | High expression levels of TLR9 and PD-L1 indicates a poor prognosis in patients with angioimmunoblastic T-cell lymphoma: a retrospective study of 88 cases in a single center |
title_sort | high expression levels of tlr9 and pd-l1 indicates a poor prognosis in patients with angioimmunoblastic t-cell lymphoma: a retrospective study of 88 cases in a single center |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930404/ https://www.ncbi.nlm.nih.gov/pubmed/31892973 http://dx.doi.org/10.7150/jca.37033 |
work_keys_str_mv | AT qianjingrong highexpressionlevelsoftlr9andpdl1indicatesapoorprognosisinpatientswithangioimmunoblastictcelllymphomaaretrospectivestudyof88casesinasinglecenter AT menghongxue highexpressionlevelsoftlr9andpdl1indicatesapoorprognosisinpatientswithangioimmunoblastictcelllymphomaaretrospectivestudyof88casesinasinglecenter AT lvbowen highexpressionlevelsoftlr9andpdl1indicatesapoorprognosisinpatientswithangioimmunoblastictcelllymphomaaretrospectivestudyof88casesinasinglecenter AT wangjie highexpressionlevelsoftlr9andpdl1indicatesapoorprognosisinpatientswithangioimmunoblastictcelllymphomaaretrospectivestudyof88casesinasinglecenter AT luyingying highexpressionlevelsoftlr9andpdl1indicatesapoorprognosisinpatientswithangioimmunoblastictcelllymphomaaretrospectivestudyof88casesinasinglecenter AT suliju highexpressionlevelsoftlr9andpdl1indicatesapoorprognosisinpatientswithangioimmunoblastictcelllymphomaaretrospectivestudyof88casesinasinglecenter AT zhaoshu highexpressionlevelsoftlr9andpdl1indicatesapoorprognosisinpatientswithangioimmunoblastictcelllymphomaaretrospectivestudyof88casesinasinglecenter AT liwenhui highexpressionlevelsoftlr9andpdl1indicatesapoorprognosisinpatientswithangioimmunoblastictcelllymphomaaretrospectivestudyof88casesinasinglecenter |