Cargando…

Preparation of Polyethylene Glycol-Ginsenoside Rh1 and Rh2 Conjugates and Their Efficacy against Lung Cancer and Inflammation

Low solubility and tumor-targeted delivery of ginsenosides to avoid off-target cytotoxicity are challenges for clinical trials. In the present study, we report on a methodology for the synthesis of polyethylene glycol (PEG)-ginsenoside conjugates through a hydrolysable ester bond using the hydrophil...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mathiyalagan, Ramya, Wang, Chao, Kim, Yeon Ju, Castro-Aceituno, Verónica, Ahn, Sungeun, Subramaniyam, Sathiyamoorthy, Simu, Shakina Yesmin, Jiménez-Pérez, Zuly Elizabeth, Yang, Deok Chun, Jung, Seok-Kyu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930446/ https://www.ncbi.nlm.nih.gov/pubmed/31795352 http://dx.doi.org/10.3390/molecules24234367

Ejemplares similares

Molecular signaling of ginsenosides Rb1, Rg1, and Rg3 and their mode of actions
por: Mohanan, Padmanaban, et al.
Publicado: (2018)

In situ preparation of water-soluble ginsenoside Rh2-entrapped bovine serum albumin nanoparticles: in vitro cytocompatibility studies
por: Singh, Priyanka, et al.
Publicado: (2017)

Glycosyltransformation of ginsenoside Rh2 into two novel ginsenosides using recombinant glycosyltransferase from Lactobacillus rhamnosus and its in vitro applications
por: Wang, Dan-Dan, et al.
Publicado: (2021)

Preliminary study on fabrication, characterization and synergistic anti-lung cancer effects of self-assembled micelles of covalently conjugated celastrol–polyethylene glycol–ginsenoside Rh2
por: Li, Peng, et al.
Publicado: (2017)

Till 2018: a survey of biomolecular sequences in genus Panax
por: Boopathi, Vinothini, et al.
Publicado: (2020)

Coalescence of functional gold and monodisperse silver nanoparticles mediated by black Panax ginseng Meyer root extract
por: Wang, Dandan, et al.
Publicado: (2016)

The interaction of serum albumin with ginsenoside Rh2 resulted in the downregulation of ginsenoside Rh2 cytotoxicity
por: Lin, Yingjia, et al.
Publicado: (2017)

Photoluminescent And Self-Assembled Hyaluronic Acid-Zinc Oxide-Ginsenoside Rh2 Nanoparticles And Their Potential Caspase-9 Apoptotic Mechanism Towards Cancer Cell Lines
por: Kim, Yeon Ju, et al.
Publicado: (2019)

Rapid green synthesis of silver and gold nanoparticles using Dendropanax morbifera leaf extract and their anticancer activities
por: Wang, Chao, et al.
Publicado: (2016)

In silico and in vitro inhibition of host-based viral entry targets and cytokine storm in COVID-19 by ginsenoside compound K
por: Boopathi, Vinothini, et al.
Publicado: (2023)

Induction of apoptosis in prostate cancer by ginsenoside Rh2
por: Tong-Lin Wu, Tony, et al.
Publicado: (2018)

Investigating the Anticancer Activity of G-Rh1 Using In Silico and In Vitro Studies (A549 Lung Cancer Cells)
por: Nahar, Jinnatun, et al.
Publicado: (2022)

Biotransformation of Ginsenoside Rf to Rh(1) by Recombinant β-Glucosidase
por: Ruan, Chang-Chun, et al.
Publicado: (2009)

Insilico profiling of microRNAs in Korean ginseng (Panax ginseng Meyer)
por: Mathiyalagan, Ramya, et al.
Publicado: (2013)

The Activation of Nrf2/HO-1 by 8-Epi-7-deoxyloganic Acid Attenuates Inflammatory Symptoms through the Suppression of the MAPK/NF-κB Signaling Cascade in In Vitro and In Vivo Models
por: Simu, Shakina Yesmin, et al.
Publicado: (2022)

Neuroprotective effects of ginsenosides Rh(1 )and Rg(2 )on neuronal cells
por: Li, Xiao-Fan, et al.
Publicado: (2011)

Probable Mechanisms of Doxorubicin Antitumor Activity Enhancement by Ginsenoside Rh2
por: Popov, Alexander, et al.
Publicado: (2022)

Structure Modification of Ginsenoside Rh(2) and Cytostatic Activity on Cancer Cells
por: Liang, Junyu, et al.
Publicado: (2023)

Rare ginsenoside Ia synthesized from F1 by cloning and overexpression of the UDP-glycosyltransferase gene from Bacillus subtilis: synthesis, characterization, and in vitro melanogenesis inhibition activity in BL6B16 cells
por: Wang, Dan-Dan, et al.
Publicado: (2018)

A Better Anti-Diabetic Recombinant Human Fibroblast Growth Factor 21 (rhFGF21) Modified with Polyethylene Glycol
por: Huang, Zhifeng, et al.
Publicado: (2011)

Synthesis of a Novel α-Glucosyl Ginsenoside F1 by Cyclodextrin Glucanotransferase and Its In Vitro Cosmetic Applications
por: Moon, Seong Soo, et al.
Publicado: (2018)

Synthesis of Stable Cholesteryl–Polyethylene Glycol–Peptide Conjugates with Non-Disperse Polyethylene Glycol Lengths
por: Cristóbal-Lecina, Edgar, et al.
Publicado: (2020)

Polyethylene glycolated PAMAM dendrimers-Efavirenz conjugates
por: Pyreddy, Suneela, et al.
Publicado: (2014)

Ginsenoside Rh2 inhibits hepatocellular carcinoma through β-catenin and autophagy
por: Yang, Zhiqing, et al.
Publicado: (2016)

Antiviral activity of 20(R)-ginsenoside Rh2 against murine gammaherpesvirus
por: Kang, Soowon, et al.
Publicado: (2017)

Synthesizing ginsenoside Rh2 in Saccharomyces cerevisiae cell factory at high-efficiency
por: Wang, Pingping, et al.
Publicado: (2019)

Mechanism-Based Pharmacokinetic Model for the Deglycosylation Kinetics of 20(S)-Ginsenosides Rh2
por: Ren, Hong-can, et al.
Publicado: (2022)

Influence of Ginsenoside Rh2 on Cardiomyocyte Pyroptosis in Rats with Acute Myocardial Infarction
por: Song, Wanmei, et al.
Publicado: (2022)

STUDIES ON BLOOD FACTORS Rh(A), Rh(B), AND Rh(C)
por: Unger, Lester J., et al.
Publicado: (1959)

Ginsenoside Rh3 induces pyroptosis and ferroptosis through the Stat3/p53/NRF2 axis in colorectal cancer cells: Ginsenoside Rh3 has anti-colorectal cancer properties
por: Wu, Yingchao, et al.
Publicado: (2023)

NMR Characterization of Polyethylene Glycol Conjugates for Nanoparticle Functionalization
por: Pasek-Allen, Jacqueline L., et al.
Publicado: (2023)

Biotransformation of ginsenosides Rb(1), Rg(3 )and Rh(2 )in rat gastrointestinal tracts
por: Qian, Tianxiu, et al.
Publicado: (2010)

The identification of molecular target of (20S) ginsenoside Rh2 for its anti-cancer activity
por: Wang, Yu-Shi, et al.
Publicado: (2017)

The activity of the saponin ginsenoside Rh2 is enhanced by the interaction with membrane sphingomyelin but depressed by cholesterol
por: Verstraeten, Sandrine L., et al.
Publicado: (2019)

Ginsenoside Rh2 enhances the antitumor immunological response of a melanoma mice model
por: Wang, Meng, et al.
Publicado: (2017)

How Does Ginsenoside Rh2 Mitigate Adipogenesis in Cultured Cells and Obese Mice?
por: Zhang, Longyun, et al.
Publicado: (2020)

Identification of 20(S)-Ginsenoside Rh2 as a Potential EGFR Tyrosine Kinase Inhibitor
por: Liang, Yuan, et al.
Publicado: (2022)

A novel autophagy activator ginsenoside Rh2 enhances the efficacy of immunogenic chemotherapy
por: Yang, Jing, et al.
Publicado: (2023)

The ways for ginsenoside Rh2 to fight against cancer: the molecular evidences in vitro and in vivo.
por: Hu, Qi-rui, et al.
Publicado: (2023)

Novel Crizotinib–GnRH Conjugates Revealed the Significance of Lysosomal Trapping in GnRH-Based Drug Delivery Systems
por: Murányi, József, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_5uspladmbdjfhldiallk0jb08h