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Phytochemical Composition and Bioactive Effects of Salvia africana, Salvia officinalis ‘Icterina’ and Salvia mexicana Aqueous Extracts
In the present study, aqueous extracts of Salvia africana, Salvia officinalis ‘Icterina’ and Savia mexicana origin were screened for their phenolic composition and for antibacterial, antioxidant, anti-inflammatory and cytotoxic properties. The three aqueous extracts contained distinct phenolic compo...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930492/ https://www.ncbi.nlm.nih.gov/pubmed/31783509 http://dx.doi.org/10.3390/molecules24234327 |
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author | Afonso, Andrea F. Pereira, Olívia R. Fernandes, Ângela Calhelha, Ricardo C. Silva, Artur M. S. Ferreira, Isabel C.F.R. Cardoso, Susana M. |
author_facet | Afonso, Andrea F. Pereira, Olívia R. Fernandes, Ângela Calhelha, Ricardo C. Silva, Artur M. S. Ferreira, Isabel C.F.R. Cardoso, Susana M. |
author_sort | Afonso, Andrea F. |
collection | PubMed |
description | In the present study, aqueous extracts of Salvia africana, Salvia officinalis ‘Icterina’ and Savia mexicana origin were screened for their phenolic composition and for antibacterial, antioxidant, anti-inflammatory and cytotoxic properties. The three aqueous extracts contained distinct phenolic compounds, with S. africana presenting the highest total levels (231.6 ± 7.5 μg/mg). Rosmarinic acid was the dominant phenolic compound in all extracts, yet that of S. africana origin was characterized by the present of yunnaneic acid isomers, which overall accounted for about 40% of total phenolics. In turn, S. officinalis ‘Icterina’ extract presented glycosidic forms of apigenin, luteolin and scuttelarein, and the one obtained from S. mexicana contained several simple caffeic acid derivatives. S. africana aqueous extract exhibited high antioxidant potential in four methods, namely the DPPH(•) (2,2-diphenyl-1-picrylhydrazyl) scavenging ability, iron-reducing power, inhibition of β-carotene bleaching and of thiobarbituric acid reactive substances (TBARS), for which EC(50) values were equal or only 1.3–3.1 higher than those of the standard compounds. Moreover, this extract was able to lower the levels of nitric oxide (NO) production in lipopolysaccharide (LPS)-activated RAW 264.7 macrophages (EC(50) = 47.8 ± 2.1 μg/mL). In addition, the three sage aqueous extracts showed promising cytotoxic effect towards hepatocellular HepG2, cervical HeLa, and breast carcinoma cells MCF-7. Overall this study highlights the potential of three little-exploited Salvia species, with commercial value for applications in food or pharmaceutical industries. |
format | Online Article Text |
id | pubmed-6930492 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-69304922019-12-26 Phytochemical Composition and Bioactive Effects of Salvia africana, Salvia officinalis ‘Icterina’ and Salvia mexicana Aqueous Extracts Afonso, Andrea F. Pereira, Olívia R. Fernandes, Ângela Calhelha, Ricardo C. Silva, Artur M. S. Ferreira, Isabel C.F.R. Cardoso, Susana M. Molecules Article In the present study, aqueous extracts of Salvia africana, Salvia officinalis ‘Icterina’ and Savia mexicana origin were screened for their phenolic composition and for antibacterial, antioxidant, anti-inflammatory and cytotoxic properties. The three aqueous extracts contained distinct phenolic compounds, with S. africana presenting the highest total levels (231.6 ± 7.5 μg/mg). Rosmarinic acid was the dominant phenolic compound in all extracts, yet that of S. africana origin was characterized by the present of yunnaneic acid isomers, which overall accounted for about 40% of total phenolics. In turn, S. officinalis ‘Icterina’ extract presented glycosidic forms of apigenin, luteolin and scuttelarein, and the one obtained from S. mexicana contained several simple caffeic acid derivatives. S. africana aqueous extract exhibited high antioxidant potential in four methods, namely the DPPH(•) (2,2-diphenyl-1-picrylhydrazyl) scavenging ability, iron-reducing power, inhibition of β-carotene bleaching and of thiobarbituric acid reactive substances (TBARS), for which EC(50) values were equal or only 1.3–3.1 higher than those of the standard compounds. Moreover, this extract was able to lower the levels of nitric oxide (NO) production in lipopolysaccharide (LPS)-activated RAW 264.7 macrophages (EC(50) = 47.8 ± 2.1 μg/mL). In addition, the three sage aqueous extracts showed promising cytotoxic effect towards hepatocellular HepG2, cervical HeLa, and breast carcinoma cells MCF-7. Overall this study highlights the potential of three little-exploited Salvia species, with commercial value for applications in food or pharmaceutical industries. MDPI 2019-11-27 /pmc/articles/PMC6930492/ /pubmed/31783509 http://dx.doi.org/10.3390/molecules24234327 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Afonso, Andrea F. Pereira, Olívia R. Fernandes, Ângela Calhelha, Ricardo C. Silva, Artur M. S. Ferreira, Isabel C.F.R. Cardoso, Susana M. Phytochemical Composition and Bioactive Effects of Salvia africana, Salvia officinalis ‘Icterina’ and Salvia mexicana Aqueous Extracts |
title | Phytochemical Composition and Bioactive Effects of Salvia africana, Salvia officinalis ‘Icterina’ and Salvia mexicana Aqueous Extracts |
title_full | Phytochemical Composition and Bioactive Effects of Salvia africana, Salvia officinalis ‘Icterina’ and Salvia mexicana Aqueous Extracts |
title_fullStr | Phytochemical Composition and Bioactive Effects of Salvia africana, Salvia officinalis ‘Icterina’ and Salvia mexicana Aqueous Extracts |
title_full_unstemmed | Phytochemical Composition and Bioactive Effects of Salvia africana, Salvia officinalis ‘Icterina’ and Salvia mexicana Aqueous Extracts |
title_short | Phytochemical Composition and Bioactive Effects of Salvia africana, Salvia officinalis ‘Icterina’ and Salvia mexicana Aqueous Extracts |
title_sort | phytochemical composition and bioactive effects of salvia africana, salvia officinalis ‘icterina’ and salvia mexicana aqueous extracts |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930492/ https://www.ncbi.nlm.nih.gov/pubmed/31783509 http://dx.doi.org/10.3390/molecules24234327 |
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