Cargando…

Phytochemical Composition and Bioactive Effects of Salvia africana, Salvia officinalis ‘Icterina’ and Salvia mexicana Aqueous Extracts

In the present study, aqueous extracts of Salvia africana, Salvia officinalis ‘Icterina’ and Savia mexicana origin were screened for their phenolic composition and for antibacterial, antioxidant, anti-inflammatory and cytotoxic properties. The three aqueous extracts contained distinct phenolic compo...

Descripción completa

Detalles Bibliográficos
Autores principales: Afonso, Andrea F., Pereira, Olívia R., Fernandes, Ângela, Calhelha, Ricardo C., Silva, Artur M. S., Ferreira, Isabel C.F.R., Cardoso, Susana M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930492/
https://www.ncbi.nlm.nih.gov/pubmed/31783509
http://dx.doi.org/10.3390/molecules24234327
_version_ 1783482904417927168
author Afonso, Andrea F.
Pereira, Olívia R.
Fernandes, Ângela
Calhelha, Ricardo C.
Silva, Artur M. S.
Ferreira, Isabel C.F.R.
Cardoso, Susana M.
author_facet Afonso, Andrea F.
Pereira, Olívia R.
Fernandes, Ângela
Calhelha, Ricardo C.
Silva, Artur M. S.
Ferreira, Isabel C.F.R.
Cardoso, Susana M.
author_sort Afonso, Andrea F.
collection PubMed
description In the present study, aqueous extracts of Salvia africana, Salvia officinalis ‘Icterina’ and Savia mexicana origin were screened for their phenolic composition and for antibacterial, antioxidant, anti-inflammatory and cytotoxic properties. The three aqueous extracts contained distinct phenolic compounds, with S. africana presenting the highest total levels (231.6 ± 7.5 μg/mg). Rosmarinic acid was the dominant phenolic compound in all extracts, yet that of S. africana origin was characterized by the present of yunnaneic acid isomers, which overall accounted for about 40% of total phenolics. In turn, S. officinalis ‘Icterina’ extract presented glycosidic forms of apigenin, luteolin and scuttelarein, and the one obtained from S. mexicana contained several simple caffeic acid derivatives. S. africana aqueous extract exhibited high antioxidant potential in four methods, namely the DPPH(•) (2,2-diphenyl-1-picrylhydrazyl) scavenging ability, iron-reducing power, inhibition of β-carotene bleaching and of thiobarbituric acid reactive substances (TBARS), for which EC(50) values were equal or only 1.3–3.1 higher than those of the standard compounds. Moreover, this extract was able to lower the levels of nitric oxide (NO) production in lipopolysaccharide (LPS)-activated RAW 264.7 macrophages (EC(50) = 47.8 ± 2.1 μg/mL). In addition, the three sage aqueous extracts showed promising cytotoxic effect towards hepatocellular HepG2, cervical HeLa, and breast carcinoma cells MCF-7. Overall this study highlights the potential of three little-exploited Salvia species, with commercial value for applications in food or pharmaceutical industries.
format Online
Article
Text
id pubmed-6930492
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-69304922019-12-26 Phytochemical Composition and Bioactive Effects of Salvia africana, Salvia officinalis ‘Icterina’ and Salvia mexicana Aqueous Extracts Afonso, Andrea F. Pereira, Olívia R. Fernandes, Ângela Calhelha, Ricardo C. Silva, Artur M. S. Ferreira, Isabel C.F.R. Cardoso, Susana M. Molecules Article In the present study, aqueous extracts of Salvia africana, Salvia officinalis ‘Icterina’ and Savia mexicana origin were screened for their phenolic composition and for antibacterial, antioxidant, anti-inflammatory and cytotoxic properties. The three aqueous extracts contained distinct phenolic compounds, with S. africana presenting the highest total levels (231.6 ± 7.5 μg/mg). Rosmarinic acid was the dominant phenolic compound in all extracts, yet that of S. africana origin was characterized by the present of yunnaneic acid isomers, which overall accounted for about 40% of total phenolics. In turn, S. officinalis ‘Icterina’ extract presented glycosidic forms of apigenin, luteolin and scuttelarein, and the one obtained from S. mexicana contained several simple caffeic acid derivatives. S. africana aqueous extract exhibited high antioxidant potential in four methods, namely the DPPH(•) (2,2-diphenyl-1-picrylhydrazyl) scavenging ability, iron-reducing power, inhibition of β-carotene bleaching and of thiobarbituric acid reactive substances (TBARS), for which EC(50) values were equal or only 1.3–3.1 higher than those of the standard compounds. Moreover, this extract was able to lower the levels of nitric oxide (NO) production in lipopolysaccharide (LPS)-activated RAW 264.7 macrophages (EC(50) = 47.8 ± 2.1 μg/mL). In addition, the three sage aqueous extracts showed promising cytotoxic effect towards hepatocellular HepG2, cervical HeLa, and breast carcinoma cells MCF-7. Overall this study highlights the potential of three little-exploited Salvia species, with commercial value for applications in food or pharmaceutical industries. MDPI 2019-11-27 /pmc/articles/PMC6930492/ /pubmed/31783509 http://dx.doi.org/10.3390/molecules24234327 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Afonso, Andrea F.
Pereira, Olívia R.
Fernandes, Ângela
Calhelha, Ricardo C.
Silva, Artur M. S.
Ferreira, Isabel C.F.R.
Cardoso, Susana M.
Phytochemical Composition and Bioactive Effects of Salvia africana, Salvia officinalis ‘Icterina’ and Salvia mexicana Aqueous Extracts
title Phytochemical Composition and Bioactive Effects of Salvia africana, Salvia officinalis ‘Icterina’ and Salvia mexicana Aqueous Extracts
title_full Phytochemical Composition and Bioactive Effects of Salvia africana, Salvia officinalis ‘Icterina’ and Salvia mexicana Aqueous Extracts
title_fullStr Phytochemical Composition and Bioactive Effects of Salvia africana, Salvia officinalis ‘Icterina’ and Salvia mexicana Aqueous Extracts
title_full_unstemmed Phytochemical Composition and Bioactive Effects of Salvia africana, Salvia officinalis ‘Icterina’ and Salvia mexicana Aqueous Extracts
title_short Phytochemical Composition and Bioactive Effects of Salvia africana, Salvia officinalis ‘Icterina’ and Salvia mexicana Aqueous Extracts
title_sort phytochemical composition and bioactive effects of salvia africana, salvia officinalis ‘icterina’ and salvia mexicana aqueous extracts
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930492/
https://www.ncbi.nlm.nih.gov/pubmed/31783509
http://dx.doi.org/10.3390/molecules24234327
work_keys_str_mv AT afonsoandreaf phytochemicalcompositionandbioactiveeffectsofsalviaafricanasalviaofficinalisicterinaandsalviamexicanaaqueousextracts
AT pereiraoliviar phytochemicalcompositionandbioactiveeffectsofsalviaafricanasalviaofficinalisicterinaandsalviamexicanaaqueousextracts
AT fernandesangela phytochemicalcompositionandbioactiveeffectsofsalviaafricanasalviaofficinalisicterinaandsalviamexicanaaqueousextracts
AT calhelharicardoc phytochemicalcompositionandbioactiveeffectsofsalviaafricanasalviaofficinalisicterinaandsalviamexicanaaqueousextracts
AT silvaarturms phytochemicalcompositionandbioactiveeffectsofsalviaafricanasalviaofficinalisicterinaandsalviamexicanaaqueousextracts
AT ferreiraisabelcfr phytochemicalcompositionandbioactiveeffectsofsalviaafricanasalviaofficinalisicterinaandsalviamexicanaaqueousextracts
AT cardososusanam phytochemicalcompositionandbioactiveeffectsofsalviaafricanasalviaofficinalisicterinaandsalviamexicanaaqueousextracts