A Prospective Repurposing of Dantrolene as a Multitarget Agent for Alzheimer’s Disease

The orphan drug dantrolene (DAN) is the only therapeutic treatment for malignant hyperthermia (MH), a pharmacogenetic pathology affecting 0.2 over 10,000 people in the EU. It acts by inhibiting ryanodine receptors, which are responsible for calcium recruitment in striatal muscles and brain. Because...

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Detalles Bibliográficos
Autores principales: Bolognino, Isabella, Giangregorio, Nicola, Pisani, Leonardo, de Candia, Modesto, Purgatorio, Rosa, Tonazzi, Annamaria, Altomare, Cosimo Damiano, Cellamare, Saverio, Catto, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930524/
https://www.ncbi.nlm.nih.gov/pubmed/31775359
http://dx.doi.org/10.3390/molecules24234298

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930524/
https://www.ncbi.nlm.nih.gov/pubmed/31775359
http://dx.doi.org/10.3390/molecules24234298

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