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A Prospective Repurposing of Dantrolene as a Multitarget Agent for Alzheimer’s Disease
The orphan drug dantrolene (DAN) is the only therapeutic treatment for malignant hyperthermia (MH), a pharmacogenetic pathology affecting 0.2 over 10,000 people in the EU. It acts by inhibiting ryanodine receptors, which are responsible for calcium recruitment in striatal muscles and brain. Because...
Autores principales: | Bolognino, Isabella, Giangregorio, Nicola, Pisani, Leonardo, de Candia, Modesto, Purgatorio, Rosa, Tonazzi, Annamaria, Altomare, Cosimo Damiano, Cellamare, Saverio, Catto, Marco |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930524/ https://www.ncbi.nlm.nih.gov/pubmed/31775359 http://dx.doi.org/10.3390/molecules24234298 |
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