Cargando…

Cytotoxic Stilbenes and Canthinone Alkaloids from Brucea antidysenterica (Simaroubaceae)

A phytochemical study of the root and bark of Brucea antidysenterica J. F. Mill. (Simaroubaceae) afforded three new compounds, including a stilbene glycoside bruceanoside A (1), and two canthinone alkaloids bruceacanthinones A (3) and B (4), along with ten known secondary metabolites, rhaponticin (2...

Descripción completa

Detalles Bibliográficos
Autores principales: Makong, Yves Salomon, Mouthé Happi, Gervais, Djouaka Bavoua, Judith Liliane, Wansi, Jean Duplex, Nahar, Lutfun, Kamdem Waffo, Alain François, Martin, Claire, Sewald, Norbert, Sarker, Satyajit Dey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930556/
https://www.ncbi.nlm.nih.gov/pubmed/31816856
http://dx.doi.org/10.3390/molecules24234412
_version_ 1783482919538393088
author Makong, Yves Salomon
Mouthé Happi, Gervais
Djouaka Bavoua, Judith Liliane
Wansi, Jean Duplex
Nahar, Lutfun
Kamdem Waffo, Alain François
Martin, Claire
Sewald, Norbert
Sarker, Satyajit Dey
author_facet Makong, Yves Salomon
Mouthé Happi, Gervais
Djouaka Bavoua, Judith Liliane
Wansi, Jean Duplex
Nahar, Lutfun
Kamdem Waffo, Alain François
Martin, Claire
Sewald, Norbert
Sarker, Satyajit Dey
author_sort Makong, Yves Salomon
collection PubMed
description A phytochemical study of the root and bark of Brucea antidysenterica J. F. Mill. (Simaroubaceae) afforded three new compounds, including a stilbene glycoside bruceanoside A (1), and two canthinone alkaloids bruceacanthinones A (3) and B (4), along with ten known secondary metabolites, rhaponticin (2), 1,11-dimethoxycanthin-6-one (5), canthin-6-one (6), 1-methoxycanthin-6-one (7), 2-methoxycanthin-6-one (8), 2-hydroxy-1,11-dimethoxycanthin-6-one (9), β-carboline-1-propionic acid (10), cleomiscosin C (11), cleomiscosin A (12), and hydnocarpin (13). The structures of all the compounds were determined using spectrometric and spectroscopic methods including 1D and 2D NMR, and HRSEIMS. The identities of the known compounds were further confirmed by comparison of their data with those reported in the literature. The root and bark methanolic extracts, the dichloromethane and ethyl acetate soluble fractions, and the isolated compounds (3–13), were assessed for their cytotoxicity against the cancer cell lines A-549, MCF-7, and PC-3. The results suggested that compounds in the extracts might possess a synergic action in their cytotoxicity.
format Online
Article
Text
id pubmed-6930556
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-69305562019-12-26 Cytotoxic Stilbenes and Canthinone Alkaloids from Brucea antidysenterica (Simaroubaceae) Makong, Yves Salomon Mouthé Happi, Gervais Djouaka Bavoua, Judith Liliane Wansi, Jean Duplex Nahar, Lutfun Kamdem Waffo, Alain François Martin, Claire Sewald, Norbert Sarker, Satyajit Dey Molecules Article A phytochemical study of the root and bark of Brucea antidysenterica J. F. Mill. (Simaroubaceae) afforded three new compounds, including a stilbene glycoside bruceanoside A (1), and two canthinone alkaloids bruceacanthinones A (3) and B (4), along with ten known secondary metabolites, rhaponticin (2), 1,11-dimethoxycanthin-6-one (5), canthin-6-one (6), 1-methoxycanthin-6-one (7), 2-methoxycanthin-6-one (8), 2-hydroxy-1,11-dimethoxycanthin-6-one (9), β-carboline-1-propionic acid (10), cleomiscosin C (11), cleomiscosin A (12), and hydnocarpin (13). The structures of all the compounds were determined using spectrometric and spectroscopic methods including 1D and 2D NMR, and HRSEIMS. The identities of the known compounds were further confirmed by comparison of their data with those reported in the literature. The root and bark methanolic extracts, the dichloromethane and ethyl acetate soluble fractions, and the isolated compounds (3–13), were assessed for their cytotoxicity against the cancer cell lines A-549, MCF-7, and PC-3. The results suggested that compounds in the extracts might possess a synergic action in their cytotoxicity. MDPI 2019-12-03 /pmc/articles/PMC6930556/ /pubmed/31816856 http://dx.doi.org/10.3390/molecules24234412 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Makong, Yves Salomon
Mouthé Happi, Gervais
Djouaka Bavoua, Judith Liliane
Wansi, Jean Duplex
Nahar, Lutfun
Kamdem Waffo, Alain François
Martin, Claire
Sewald, Norbert
Sarker, Satyajit Dey
Cytotoxic Stilbenes and Canthinone Alkaloids from Brucea antidysenterica (Simaroubaceae)
title Cytotoxic Stilbenes and Canthinone Alkaloids from Brucea antidysenterica (Simaroubaceae)
title_full Cytotoxic Stilbenes and Canthinone Alkaloids from Brucea antidysenterica (Simaroubaceae)
title_fullStr Cytotoxic Stilbenes and Canthinone Alkaloids from Brucea antidysenterica (Simaroubaceae)
title_full_unstemmed Cytotoxic Stilbenes and Canthinone Alkaloids from Brucea antidysenterica (Simaroubaceae)
title_short Cytotoxic Stilbenes and Canthinone Alkaloids from Brucea antidysenterica (Simaroubaceae)
title_sort cytotoxic stilbenes and canthinone alkaloids from brucea antidysenterica (simaroubaceae)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930556/
https://www.ncbi.nlm.nih.gov/pubmed/31816856
http://dx.doi.org/10.3390/molecules24234412
work_keys_str_mv AT makongyvessalomon cytotoxicstilbenesandcanthinonealkaloidsfrombruceaantidysentericasimaroubaceae
AT mouthehappigervais cytotoxicstilbenesandcanthinonealkaloidsfrombruceaantidysentericasimaroubaceae
AT djouakabavouajudithliliane cytotoxicstilbenesandcanthinonealkaloidsfrombruceaantidysentericasimaroubaceae
AT wansijeanduplex cytotoxicstilbenesandcanthinonealkaloidsfrombruceaantidysentericasimaroubaceae
AT naharlutfun cytotoxicstilbenesandcanthinonealkaloidsfrombruceaantidysentericasimaroubaceae
AT kamdemwaffoalainfrancois cytotoxicstilbenesandcanthinonealkaloidsfrombruceaantidysentericasimaroubaceae
AT martinclaire cytotoxicstilbenesandcanthinonealkaloidsfrombruceaantidysentericasimaroubaceae
AT sewaldnorbert cytotoxicstilbenesandcanthinonealkaloidsfrombruceaantidysentericasimaroubaceae
AT sarkersatyajitdey cytotoxicstilbenesandcanthinonealkaloidsfrombruceaantidysentericasimaroubaceae