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Cytotoxic Stilbenes and Canthinone Alkaloids from Brucea antidysenterica (Simaroubaceae)
A phytochemical study of the root and bark of Brucea antidysenterica J. F. Mill. (Simaroubaceae) afforded three new compounds, including a stilbene glycoside bruceanoside A (1), and two canthinone alkaloids bruceacanthinones A (3) and B (4), along with ten known secondary metabolites, rhaponticin (2...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930556/ https://www.ncbi.nlm.nih.gov/pubmed/31816856 http://dx.doi.org/10.3390/molecules24234412 |
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author | Makong, Yves Salomon Mouthé Happi, Gervais Djouaka Bavoua, Judith Liliane Wansi, Jean Duplex Nahar, Lutfun Kamdem Waffo, Alain François Martin, Claire Sewald, Norbert Sarker, Satyajit Dey |
author_facet | Makong, Yves Salomon Mouthé Happi, Gervais Djouaka Bavoua, Judith Liliane Wansi, Jean Duplex Nahar, Lutfun Kamdem Waffo, Alain François Martin, Claire Sewald, Norbert Sarker, Satyajit Dey |
author_sort | Makong, Yves Salomon |
collection | PubMed |
description | A phytochemical study of the root and bark of Brucea antidysenterica J. F. Mill. (Simaroubaceae) afforded three new compounds, including a stilbene glycoside bruceanoside A (1), and two canthinone alkaloids bruceacanthinones A (3) and B (4), along with ten known secondary metabolites, rhaponticin (2), 1,11-dimethoxycanthin-6-one (5), canthin-6-one (6), 1-methoxycanthin-6-one (7), 2-methoxycanthin-6-one (8), 2-hydroxy-1,11-dimethoxycanthin-6-one (9), β-carboline-1-propionic acid (10), cleomiscosin C (11), cleomiscosin A (12), and hydnocarpin (13). The structures of all the compounds were determined using spectrometric and spectroscopic methods including 1D and 2D NMR, and HRSEIMS. The identities of the known compounds were further confirmed by comparison of their data with those reported in the literature. The root and bark methanolic extracts, the dichloromethane and ethyl acetate soluble fractions, and the isolated compounds (3–13), were assessed for their cytotoxicity against the cancer cell lines A-549, MCF-7, and PC-3. The results suggested that compounds in the extracts might possess a synergic action in their cytotoxicity. |
format | Online Article Text |
id | pubmed-6930556 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-69305562019-12-26 Cytotoxic Stilbenes and Canthinone Alkaloids from Brucea antidysenterica (Simaroubaceae) Makong, Yves Salomon Mouthé Happi, Gervais Djouaka Bavoua, Judith Liliane Wansi, Jean Duplex Nahar, Lutfun Kamdem Waffo, Alain François Martin, Claire Sewald, Norbert Sarker, Satyajit Dey Molecules Article A phytochemical study of the root and bark of Brucea antidysenterica J. F. Mill. (Simaroubaceae) afforded three new compounds, including a stilbene glycoside bruceanoside A (1), and two canthinone alkaloids bruceacanthinones A (3) and B (4), along with ten known secondary metabolites, rhaponticin (2), 1,11-dimethoxycanthin-6-one (5), canthin-6-one (6), 1-methoxycanthin-6-one (7), 2-methoxycanthin-6-one (8), 2-hydroxy-1,11-dimethoxycanthin-6-one (9), β-carboline-1-propionic acid (10), cleomiscosin C (11), cleomiscosin A (12), and hydnocarpin (13). The structures of all the compounds were determined using spectrometric and spectroscopic methods including 1D and 2D NMR, and HRSEIMS. The identities of the known compounds were further confirmed by comparison of their data with those reported in the literature. The root and bark methanolic extracts, the dichloromethane and ethyl acetate soluble fractions, and the isolated compounds (3–13), were assessed for their cytotoxicity against the cancer cell lines A-549, MCF-7, and PC-3. The results suggested that compounds in the extracts might possess a synergic action in their cytotoxicity. MDPI 2019-12-03 /pmc/articles/PMC6930556/ /pubmed/31816856 http://dx.doi.org/10.3390/molecules24234412 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Makong, Yves Salomon Mouthé Happi, Gervais Djouaka Bavoua, Judith Liliane Wansi, Jean Duplex Nahar, Lutfun Kamdem Waffo, Alain François Martin, Claire Sewald, Norbert Sarker, Satyajit Dey Cytotoxic Stilbenes and Canthinone Alkaloids from Brucea antidysenterica (Simaroubaceae) |
title | Cytotoxic Stilbenes and Canthinone Alkaloids from Brucea antidysenterica (Simaroubaceae) |
title_full | Cytotoxic Stilbenes and Canthinone Alkaloids from Brucea antidysenterica (Simaroubaceae) |
title_fullStr | Cytotoxic Stilbenes and Canthinone Alkaloids from Brucea antidysenterica (Simaroubaceae) |
title_full_unstemmed | Cytotoxic Stilbenes and Canthinone Alkaloids from Brucea antidysenterica (Simaroubaceae) |
title_short | Cytotoxic Stilbenes and Canthinone Alkaloids from Brucea antidysenterica (Simaroubaceae) |
title_sort | cytotoxic stilbenes and canthinone alkaloids from brucea antidysenterica (simaroubaceae) |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930556/ https://www.ncbi.nlm.nih.gov/pubmed/31816856 http://dx.doi.org/10.3390/molecules24234412 |
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