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Discovery of a Potent PLK1-PBD Small-Molecule Inhibitor as an Anticancer Drug Candidate through Structure-Based Design

Polo-box domain of polo-like kinase 1 (PLK1-PBD) has a pivotal role in cell proliferation and could be implicated as a potential anticancer target. Although some small-molecule inhibitors have been developed, their clinical application has been restricted by the poor selectivity. Therefore, there is...

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Detalles Bibliográficos
Autores principales:	Zhou, Yunjiang, Yan, Fang, Huo, Xiangyun, Niu, Miao-Miao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930574/ https://www.ncbi.nlm.nih.gov/pubmed/31795214 http://dx.doi.org/10.3390/molecules24234351

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