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Synthetic Strategies for Dinucleotides Synthesis
Dinucleoside 5′,5′-polyphosphates (DNPs) are endogenous substances that play important intra- and extracellular roles in various biological processes, such as cell proliferation, regulation of enzymes, neurotransmission, platelet disaggregation and modulation of vascular tone. Various methodologies...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930578/ https://www.ncbi.nlm.nih.gov/pubmed/31783537 http://dx.doi.org/10.3390/molecules24234334 |
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author | Appy, Lucie Chardet, Crystalle Peyrottes, Suzanne Roy, Béatrice |
author_facet | Appy, Lucie Chardet, Crystalle Peyrottes, Suzanne Roy, Béatrice |
author_sort | Appy, Lucie |
collection | PubMed |
description | Dinucleoside 5′,5′-polyphosphates (DNPs) are endogenous substances that play important intra- and extracellular roles in various biological processes, such as cell proliferation, regulation of enzymes, neurotransmission, platelet disaggregation and modulation of vascular tone. Various methodologies have been developed over the past fifty years to access these compounds, involving enzymatic processes or chemical procedures based either on P(III) or P(V) chemistry. Both solution-phase and solid-support strategies have been developed and are reported here. Recently, green chemistry approaches have emerged, offering attracting alternatives. This review outlines the main synthetic pathways for the preparation of dinucleoside 5′,5′-polyphosphates, focusing on pharmacologically relevant compounds, and highlighting recent advances. |
format | Online Article Text |
id | pubmed-6930578 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-69305782019-12-26 Synthetic Strategies for Dinucleotides Synthesis Appy, Lucie Chardet, Crystalle Peyrottes, Suzanne Roy, Béatrice Molecules Review Dinucleoside 5′,5′-polyphosphates (DNPs) are endogenous substances that play important intra- and extracellular roles in various biological processes, such as cell proliferation, regulation of enzymes, neurotransmission, platelet disaggregation and modulation of vascular tone. Various methodologies have been developed over the past fifty years to access these compounds, involving enzymatic processes or chemical procedures based either on P(III) or P(V) chemistry. Both solution-phase and solid-support strategies have been developed and are reported here. Recently, green chemistry approaches have emerged, offering attracting alternatives. This review outlines the main synthetic pathways for the preparation of dinucleoside 5′,5′-polyphosphates, focusing on pharmacologically relevant compounds, and highlighting recent advances. MDPI 2019-11-27 /pmc/articles/PMC6930578/ /pubmed/31783537 http://dx.doi.org/10.3390/molecules24234334 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Appy, Lucie Chardet, Crystalle Peyrottes, Suzanne Roy, Béatrice Synthetic Strategies for Dinucleotides Synthesis |
title | Synthetic Strategies for Dinucleotides Synthesis |
title_full | Synthetic Strategies for Dinucleotides Synthesis |
title_fullStr | Synthetic Strategies for Dinucleotides Synthesis |
title_full_unstemmed | Synthetic Strategies for Dinucleotides Synthesis |
title_short | Synthetic Strategies for Dinucleotides Synthesis |
title_sort | synthetic strategies for dinucleotides synthesis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930578/ https://www.ncbi.nlm.nih.gov/pubmed/31783537 http://dx.doi.org/10.3390/molecules24234334 |
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