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Synthetic Strategies for Dinucleotides Synthesis

Dinucleoside 5′,5′-polyphosphates (DNPs) are endogenous substances that play important intra- and extracellular roles in various biological processes, such as cell proliferation, regulation of enzymes, neurotransmission, platelet disaggregation and modulation of vascular tone. Various methodologies...

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Detalles Bibliográficos
Autores principales: Appy, Lucie, Chardet, Crystalle, Peyrottes, Suzanne, Roy, Béatrice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930578/
https://www.ncbi.nlm.nih.gov/pubmed/31783537
http://dx.doi.org/10.3390/molecules24234334
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author Appy, Lucie
Chardet, Crystalle
Peyrottes, Suzanne
Roy, Béatrice
author_facet Appy, Lucie
Chardet, Crystalle
Peyrottes, Suzanne
Roy, Béatrice
author_sort Appy, Lucie
collection PubMed
description Dinucleoside 5′,5′-polyphosphates (DNPs) are endogenous substances that play important intra- and extracellular roles in various biological processes, such as cell proliferation, regulation of enzymes, neurotransmission, platelet disaggregation and modulation of vascular tone. Various methodologies have been developed over the past fifty years to access these compounds, involving enzymatic processes or chemical procedures based either on P(III) or P(V) chemistry. Both solution-phase and solid-support strategies have been developed and are reported here. Recently, green chemistry approaches have emerged, offering attracting alternatives. This review outlines the main synthetic pathways for the preparation of dinucleoside 5′,5′-polyphosphates, focusing on pharmacologically relevant compounds, and highlighting recent advances.
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spelling pubmed-69305782019-12-26 Synthetic Strategies for Dinucleotides Synthesis Appy, Lucie Chardet, Crystalle Peyrottes, Suzanne Roy, Béatrice Molecules Review Dinucleoside 5′,5′-polyphosphates (DNPs) are endogenous substances that play important intra- and extracellular roles in various biological processes, such as cell proliferation, regulation of enzymes, neurotransmission, platelet disaggregation and modulation of vascular tone. Various methodologies have been developed over the past fifty years to access these compounds, involving enzymatic processes or chemical procedures based either on P(III) or P(V) chemistry. Both solution-phase and solid-support strategies have been developed and are reported here. Recently, green chemistry approaches have emerged, offering attracting alternatives. This review outlines the main synthetic pathways for the preparation of dinucleoside 5′,5′-polyphosphates, focusing on pharmacologically relevant compounds, and highlighting recent advances. MDPI 2019-11-27 /pmc/articles/PMC6930578/ /pubmed/31783537 http://dx.doi.org/10.3390/molecules24234334 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Appy, Lucie
Chardet, Crystalle
Peyrottes, Suzanne
Roy, Béatrice
Synthetic Strategies for Dinucleotides Synthesis
title Synthetic Strategies for Dinucleotides Synthesis
title_full Synthetic Strategies for Dinucleotides Synthesis
title_fullStr Synthetic Strategies for Dinucleotides Synthesis
title_full_unstemmed Synthetic Strategies for Dinucleotides Synthesis
title_short Synthetic Strategies for Dinucleotides Synthesis
title_sort synthetic strategies for dinucleotides synthesis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930578/
https://www.ncbi.nlm.nih.gov/pubmed/31783537
http://dx.doi.org/10.3390/molecules24234334
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