Cargando…

Synthesis and Evaluation of Novel 2H-Benzo[e]-[1,2,4]thiadiazine 1,1-Dioxide Derivatives as PI3Kδ Inhibitors

In previous work, we applied the rotation-limiting strategy and introduced a substituent at the 3-position of the pyrazolo [3,4-d]pyrimidin-4-amine as the affinity element to interact with the deeper hydrophobic pocket, discovered a series of novel quinazolinones as potent PI3Kδ inhibitors. Among th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gong, Ya-Ping, Tang, Long-Qian, Liu, Tong-Shen, Liu, Zhao-Peng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930582/ https://www.ncbi.nlm.nih.gov/pubmed/31775363 http://dx.doi.org/10.3390/molecules24234299

Ejemplares similares

Synthesis and biological activity of novel 3-heteroaryl-2H-pyrido[4,3-e][1,2,4]thiadiazine and 3-heteroaryl-2H-benzo[e][1,2,4]thiadiazine 1,1-dioxides
por: Gobis, Katarzyna, et al.
Publicado: (2013)

Synthesis of Novel Pyrido[4,3-e][1,2,4]triazino[3,2-c][1,2,4]thiadiazine 6,6-dioxide Derivatives with Potential Anticancer Activity
por: Sławiński, Jarosław, et al.
Publicado: (2015)

Vision on Synthetic and Medicinal Facets of 1,2,4-Triazolo[3,4-b][1,3,4]thiadiazine Scaffold
por: Aggarwal, Ranjana, et al.
Publicado: (2022)

Synthesis and antimicrobial activity of some novel fused heterocyclic 1,2,4-triazolo [3,4-b][1,3,4] thiadiazine derivatives
por: Sahu, Jagdish K., et al.
Publicado: (2014)

Efficient synthesis of chiral 2,3-dihydro-benzo[b]thiophene 1,1-dioxides via Rh-catalyzed hydrogenation
por: Liu, Gongyi, et al.
Publicado: (2019)

2-(6-Phenyl-7H-1,2,4-triazolo[3,4-b][1,3,4]thiadiazin-3-yl)-1,3-benzothiazole
por: Abdel-Aziz, Hatem A., et al.
Publicado: (2011)

3-(3-Chlorobenzoyl)-4-hydroxy-2H-1,2-benzothiazine 1,1-dioxide
por: Khalid, Zunera, et al.
Publicado: (2010)

Ethyl 2-(3,5-dimethyl-1,1-dioxo-2H-1λ(6),2,6-thiadiazin-4-yl)benzoate
por: Bhatt, Nilay, et al.
Publicado: (2012)

2-(3,5-Dimethyl-1,1-dioxo-2H-1λ(6),2,6-thiadiazin-4-yl)benzoic acid
por: Bhatt, Nilay, et al.
Publicado: (2012)

Palladium-Catalyzed C2-Selective Oxidative Olefination of Benzo[b]thiophene 1,1-Dioxides with Styrenes and Acrylates
por: Yang, Bingbin, et al.
Publicado: (2023)

Synthesis and anti-tubercular activity of 3-substituted benzo[b]thiophene-1,1-dioxides
por: Chandrasekera, N. Susantha, et al.
Publicado: (2014)

3-Ethyl-6-(4-fluorophenyl)-7H-1,2,4-triazolo[3,4-b][1,3,4]thiadiazine
por: Jeyaseelan, S., et al.
Publicado: (2012)

6-(4-Bromophenyl)-3-methyl-7H-1,2,4-triazolo[3,4-b][1,3,4]thiadiazine
por: Fun, Hoong-Kun, et al.
Publicado: (2012)

Design, Synthesis, and Biological Evaluation of Novel 7H-[1,2,4]Triazolo[3,4-b][1,3,4]thiadiazine Inhibitors as Antitumor Agents
por: Ismail, Muhammad I., et al.
Publicado: (2020)

Methyl 2-(2,3,5-trimethyl-1,1-dioxo-2H-1λ(6),2,6-thiadiazin-4-yl)benzoate
por: Bhatt, Nilay, et al.
Publicado: (2012)

Synthesis of novel 1,2,4-thiadiazinane 1,1-dioxides via three component SuFEx type reaction
por: Khumalo, Mzilikazi F., et al.
Publicado: (2018)

Methyl 2-ethyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide
por: Arshad, Muhammad Nadeem, et al.
Publicado: (2010)

4-Hydroxy-2-[(4-iodobenzoyl)methyl]-3-(3-methoxybenzoyl)-2H-1,2-benzothiazine 1,1-dioxide
por: Gul, Salman, et al.
Publicado: (2010)

Toxicological evaluation of the flavour ingredient N-(1-((4-amino-2,2-dioxido-1H-benzo[c][1,2,6]thiadiazin-5-yl)oxy)-2-methylpropan-2-yl)-2,6-dimethylisonicotinamide (S2218)
por: Karanewsky, Donald S., et al.
Publicado: (2017)

Novel [1,2,4]triazolo[3,4-b][1,3,4]thiadiazine and [1,2,4]triazolo[3,4-b][1,3,4]thiadiazepine Derivatives: Synthesis, Anti-Viral In Vitro Study and Target Validation Activity
por: Khramchikhin, Andrey V., et al.
Publicado: (2022)

Crystal structure of 1-fluoro-1,3-dihydrobenzo[c]thiophene 2,2-dioxide
por: Zou, Ying, et al.
Publicado: (2015)

Spiro[indene-1,1′-benzo[e]indolin]-2′-one
por: Chen, Jin-Xiang, et al.
Publicado: (2010)

6-(4-Fluorophenyl)-3-phenyl-7H-1,2,4-triazolo[3,4-b][1,3,4]thiadiazine
por: Palakshamurthy, B. S., et al.
Publicado: (2014)

Synthesis and Pharmacological Studies of Unprecedented Fused Pyridazino[3′,4′:5,6][1,2,4]triazino[3,4-b][1,3,4]thiadiazine Derivatives
por: Ali, Rania S., et al.
Publicado: (2018)

Electrochemically-promoted synthesis of benzo[b]thiophene-1,1-dioxides via strained quaternary spirocyclization
por: Li, Ruitao, et al.
Publicado: (2022)

2-Phenyl-8,9,10,11-tetrahydro-1-benzothieno[3,2-e][1,2,4]triazolo[1,5-c]pyrimidine
por: Panchamukhi, Shridhar I., et al.
Publicado: (2011)

Synthesis, Characterization, and Antifungal Activity of Novel Benzo[4,5]imidazo[1,2-d][1,2,4]triazine Derivatives
por: Li, Ling-Xia, et al.
Publicado: (2018)

Synthesis and Anti-Breast Cancer Potency of Mono- and Bis-(pyrazolyl[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine) Derivatives as EGFR/CDK-2 Target Inhibitors
por: Salem, Mostafa E., et al.
Publicado: (2023)

Synthesis and Biological Evaluation of Some Novel 5-[(3-Aralkyl Amido/Imidoalkyl) Phenyl]-1,2,4-Triazolo[3,4-b]-1,3,4-Thiadiazines as Antiviral Agents
por: Pandey, Vinod Kumar, et al.
Publicado: (2012)

Design, synthesis and structure-activity relationship of 3,6-diaryl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines as novel tubulin inhibitors
por: Xu, Qile, et al.
Publicado: (2017)

4-[3-(1-Naphthyloxymethyl)-7H-1,2,4-triazolo[3,4-b][1,3,4]thiadiazin-6-yl]-3-p-tolylsydnone
por: Goh, Jia Hao, et al.
Publicado: (2010)

Cyclization of substitued 2-(2-fluorophenylazo)azines to azino[1,2-c]benzo[d][1,2,4]triazinium derivatives
por: Jankowiak, Aleksandra, et al.
Publicado: (2013)

Crystal structure of (R)-6′-bromo-3,3-dimethyl-3′,4′-dihydro-2′H-spiro[cyclohexane-1,3′-1,2,4-benzothiadiazine] 1′,1′-dioxide
por: Shinoj Kumar, P. P., et al.
Publicado: (2014)

Simultaneous targeting of PI3Kδ and a PI3Kδ-dependent MEK1/2-Erk1/2 pathway for therapy in pediatric B-cell acute lymphoblastic leukemia
por: Wang, Xiang, et al.
Publicado: (2014)

Scientific Opinion of Flavouring Group Evaluation 406 (FGE.406): (S)‐1‐(3‐(((4‐amino‐2,2‐dioxido‐1H‐benzo[c][1,2,6]thiadiazin‐5‐yl)oxy)methyl)piperidin‐1‐yl)‐3‐methylbutan‐1‐one
por: Silano, Vittorio, et al.
Publicado: (2018)

Discovery of ( ±)-3-(1 H -pyrazol-1-yl)-6,7-dihydro-5 H -[1,2,4]triazolo[3,4- b ][1,3,4] thiadiazine derivatives with promising in vitro anticoronavirus and antitumoral activity
por: Jilloju, Parameshwara Chary, et al.
Publicado: (2021)

Benzo[b]thiophenesulphonamide 1,1-dioxide derivatives inhibit tNOX activity in a redox state-dependent manner
por: Encío, I, et al.
Publicado: (2005)

3-Phenyl-4-{3-[(p-tolyloxy)methyl]-7H-1,2,4-triazolo[3,4-b][1,3,4]thiadiazin-6-yl}sydnone
por: Goh, Jia Hao, et al.
Publicado: (2010)

2,5-Dichlorothiophene 1,1-dioxide
por: Briggs, Jonathan B., et al.
Publicado: (2009)

2,5-Dihexylthiophene 1,1-dioxide
por: Van Tonder, Johannes, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_42ct5i0bm05mkmq6s0nee666j2