Path Integral Calculation of the Hydrogen/Deuterium Kinetic Isotope Effect in Monoamine Oxidase A-Catalyzed Decomposition of Benzylamine

Monoamine oxidase A (MAO A) is a well-known enzyme responsible for the oxidative deamination of several important monoaminergic neurotransmitters. The rate-limiting step of amine decomposition is hydride anion transfer from the substrate α–CH2 group to the N5 atom of the flavin cofactor moiety. In t...

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Detalles Bibliográficos
Autores principales: Brela, Mateusz Z., Prah, Alja, Boczar, Marek, Stare, Jernej, Mavri, Janez
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930584/
https://www.ncbi.nlm.nih.gov/pubmed/31795294
http://dx.doi.org/10.3390/molecules24234359

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930584/
https://www.ncbi.nlm.nih.gov/pubmed/31795294
http://dx.doi.org/10.3390/molecules24234359

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