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Concepts and Core Principles of Fragment-Based Drug Design

In this review, a general introduction to fragment-based drug design and the underlying concepts is given. General considerations and methodologies ranging from library selection/construction over biophysical screening and evaluation methods to in-depth hit qualification and subsequent optimization...

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Detalles Bibliográficos
Autores principales: Kirsch, Philine, Hartman, Alwin M., Hirsch, Anna K. H., Empting, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930586/
https://www.ncbi.nlm.nih.gov/pubmed/31779114
http://dx.doi.org/10.3390/molecules24234309