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Thiyl Radical Reactions in the Chemical Degradation of Pharmaceutical Proteins

Free radical pathways play a major role in the degradation of protein pharmaceuticals. Inspired by biochemical reactions carried out by thiyl radicals in various enzymatic processes, this review focuses on the role of thiyl radicals in pharmaceutical protein degradation through hydrogen atom transfe...

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Detalles Bibliográficos
Autor principal: Schöneich, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930596/
https://www.ncbi.nlm.nih.gov/pubmed/31795282
http://dx.doi.org/10.3390/molecules24234357
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author Schöneich, Christian
author_facet Schöneich, Christian
author_sort Schöneich, Christian
collection PubMed
description Free radical pathways play a major role in the degradation of protein pharmaceuticals. Inspired by biochemical reactions carried out by thiyl radicals in various enzymatic processes, this review focuses on the role of thiyl radicals in pharmaceutical protein degradation through hydrogen atom transfer, electron transfer, and addition reactions. These processes can lead to the epimerization of amino acids, as well as the formation of various cleavage products and cross-links. Examples are presented for human insulin, human and mouse growth hormone, and monoclonal antibodies.
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spelling pubmed-69305962019-12-26 Thiyl Radical Reactions in the Chemical Degradation of Pharmaceutical Proteins Schöneich, Christian Molecules Review Free radical pathways play a major role in the degradation of protein pharmaceuticals. Inspired by biochemical reactions carried out by thiyl radicals in various enzymatic processes, this review focuses on the role of thiyl radicals in pharmaceutical protein degradation through hydrogen atom transfer, electron transfer, and addition reactions. These processes can lead to the epimerization of amino acids, as well as the formation of various cleavage products and cross-links. Examples are presented for human insulin, human and mouse growth hormone, and monoclonal antibodies. MDPI 2019-11-28 /pmc/articles/PMC6930596/ /pubmed/31795282 http://dx.doi.org/10.3390/molecules24234357 Text en © 2019 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Schöneich, Christian
Thiyl Radical Reactions in the Chemical Degradation of Pharmaceutical Proteins
title Thiyl Radical Reactions in the Chemical Degradation of Pharmaceutical Proteins
title_full Thiyl Radical Reactions in the Chemical Degradation of Pharmaceutical Proteins
title_fullStr Thiyl Radical Reactions in the Chemical Degradation of Pharmaceutical Proteins
title_full_unstemmed Thiyl Radical Reactions in the Chemical Degradation of Pharmaceutical Proteins
title_short Thiyl Radical Reactions in the Chemical Degradation of Pharmaceutical Proteins
title_sort thiyl radical reactions in the chemical degradation of pharmaceutical proteins
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930596/
https://www.ncbi.nlm.nih.gov/pubmed/31795282
http://dx.doi.org/10.3390/molecules24234357
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