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Synthesis and In Vitro Evaluation of Novel Liver X Receptor Agonists Based on Naphthoquinone Derivatives

We aimed to synthesize novel liver X receptor (LXR) agonists with potent agonist activity and subtype selectivity. Our synthetic scheme started with naphthoquinone derivatives, such as menadione and 2,3-dichloro-1,4-naphthoquinone. We introduced different substituents into the naphthoquinone structu...

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Detalles Bibliográficos
Autores principales:	Nishioka, Tatsuma, Endo-Umeda, Kaori, Ito, Yuki, Shimoda, Akane, Takeuchi, Atsuko, Tode, Chisato, Hirota, Yoshihisa, Osakabe, Naomi, Makishima, Makoto, Suhara, Yoshitomo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930623/ https://www.ncbi.nlm.nih.gov/pubmed/31779181 http://dx.doi.org/10.3390/molecules24234316

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