Michael Addition Reaction Catalyzed by Imidazolium Chloride to Protect Amino Groups and Construct Medium Ring Heterocycles

An effective approach for amino protection and construction of a seven-membered ring has been developed. The method uses imidazolium chloride to carry out the Michael addition reaction at low temperatures and perform amino deprotection or construction of a seven-membered ring at high temperatures.

Detalles Bibliográficos
Autores principales: Dai, Zeshu, Tian, Qingqiang, Li, Yanwu, Shang, Suqin, Luo, Wen, Wang, Xuetong, Li, Dan, Zhang, Ying, Li, Zhiyao, Yuan, Jianyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930643/
https://www.ncbi.nlm.nih.gov/pubmed/31757097
http://dx.doi.org/10.3390/molecules24234224
Descripción
Sumario:An effective approach for amino protection and construction of a seven-membered ring has been developed. The method uses imidazolium chloride to carry out the Michael addition reaction at low temperatures and perform amino deprotection or construction of a seven-membered ring at high temperatures.

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