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Pharmacokinetics of Capecitabine and Four Metabolites in a Heterogeneous Population of Cancer Patients: A Comprehensive Analysis

Capecitabine is an oral prodrug of the anticancer drug 5‐fluorouracil (5‐FU). The primary aim of this study was to develop a pharmacokinetic model for capecitabine and its metabolites, 5′‐deoxy‐5‐fluorocytidine (dFCR), 5′‐deoxy‐5‐fluorouridine (dFUR), 5‐FU, and fluoro‐β‐alanine (FBAL) using data fro...

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Detalles Bibliográficos
Autores principales:	Jacobs, Bart A.W., Deenen, Maarten J., Joerger, Markus, Rosing, Hilde, de Vries, Niels, Meulendijks, Didier, Cats, Annemieke, Beijnen, Jos H., Schellens, Jan H.M., Huitema, Alwin D.R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930859/ https://www.ncbi.nlm.nih.gov/pubmed/31652031 http://dx.doi.org/10.1002/psp4.12474

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