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Population Pharmacokinetic/Pharmacodynamic Modeling of Methylprednisolone in Neonates Undergoing Cardiopulmonary Bypass

Methylprednisolone is used in neonates to modulate cardiopulmonary bypass (CPB)–induced inflammation, but optimal dosing and exposure are unknown. We used plasma methylprednisolone and interleukin (IL)‐6 and IL‐10 concentrations from neonates enrolled in a randomized trial comparing one vs. two dose...

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Detalles Bibliográficos
Autores principales:	Hornik, Christoph P., Gonzalez, Daniel, Dumond, Julie, Wu, Huali, Graham, Eric M., Hill, Kevin D., Cohen‐Wolkowiez, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930860/ https://www.ncbi.nlm.nih.gov/pubmed/31646767 http://dx.doi.org/10.1002/psp4.12470

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