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N(6)-Methyladenosine: A Novel RNA Imprint in Human Cancer

N(6)-Methyladenosine (m(6)A), a pervasive posttranscriptional modification which is reversible, has been among hotspot issues in the past several years. The balance of intracellular m(6)A levels is dynamically maintained by methyltransferase complex and demethylases. Meanwhile, m(6)A reader proteins...

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Autores principales: Yu, Sihui, Li, Xi, Liu, Shiyun, Yang, Rui, Liu, Xiangnan, Wu, Sufang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930912/
https://www.ncbi.nlm.nih.gov/pubmed/31921664
http://dx.doi.org/10.3389/fonc.2019.01407
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author Yu, Sihui
Li, Xi
Liu, Shiyun
Yang, Rui
Liu, Xiangnan
Wu, Sufang
author_facet Yu, Sihui
Li, Xi
Liu, Shiyun
Yang, Rui
Liu, Xiangnan
Wu, Sufang
author_sort Yu, Sihui
collection PubMed
description N(6)-Methyladenosine (m(6)A), a pervasive posttranscriptional modification which is reversible, has been among hotspot issues in the past several years. The balance of intracellular m(6)A levels is dynamically maintained by methyltransferase complex and demethylases. Meanwhile, m(6)A reader proteins specifically recognize modified residues and convey messages so as to set up an efficient and orderly network of m(6)A regulation. The m(6)A mark has proved to affect every step of RNA life cycle, from processing in nucleus to translation or degradation in cytoplasm. Subsequently, disorders in m(6)A methylation are directly related to aberrant RNA metabolism, which results in tumorigenesis and altered drug response. Therefore, uncovering the underlying mechanism of m(6)A in oncogenic transformation and tumor progression seeks opportunities for novel targets in cancer therapy. In this review, we conclude the extensive impact of m(6)A on RNA metabolism and highlight its relevance with human cancer, implicating the far-reaching value in clinical application.
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spelling pubmed-69309122020-01-09 N(6)-Methyladenosine: A Novel RNA Imprint in Human Cancer Yu, Sihui Li, Xi Liu, Shiyun Yang, Rui Liu, Xiangnan Wu, Sufang Front Oncol Oncology N(6)-Methyladenosine (m(6)A), a pervasive posttranscriptional modification which is reversible, has been among hotspot issues in the past several years. The balance of intracellular m(6)A levels is dynamically maintained by methyltransferase complex and demethylases. Meanwhile, m(6)A reader proteins specifically recognize modified residues and convey messages so as to set up an efficient and orderly network of m(6)A regulation. The m(6)A mark has proved to affect every step of RNA life cycle, from processing in nucleus to translation or degradation in cytoplasm. Subsequently, disorders in m(6)A methylation are directly related to aberrant RNA metabolism, which results in tumorigenesis and altered drug response. Therefore, uncovering the underlying mechanism of m(6)A in oncogenic transformation and tumor progression seeks opportunities for novel targets in cancer therapy. In this review, we conclude the extensive impact of m(6)A on RNA metabolism and highlight its relevance with human cancer, implicating the far-reaching value in clinical application. Frontiers Media S.A. 2019-12-19 /pmc/articles/PMC6930912/ /pubmed/31921664 http://dx.doi.org/10.3389/fonc.2019.01407 Text en Copyright © 2019 Yu, Li, Liu, Yang, Liu and Wu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Yu, Sihui
Li, Xi
Liu, Shiyun
Yang, Rui
Liu, Xiangnan
Wu, Sufang
N(6)-Methyladenosine: A Novel RNA Imprint in Human Cancer
title N(6)-Methyladenosine: A Novel RNA Imprint in Human Cancer
title_full N(6)-Methyladenosine: A Novel RNA Imprint in Human Cancer
title_fullStr N(6)-Methyladenosine: A Novel RNA Imprint in Human Cancer
title_full_unstemmed N(6)-Methyladenosine: A Novel RNA Imprint in Human Cancer
title_short N(6)-Methyladenosine: A Novel RNA Imprint in Human Cancer
title_sort n(6)-methyladenosine: a novel rna imprint in human cancer
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930912/
https://www.ncbi.nlm.nih.gov/pubmed/31921664
http://dx.doi.org/10.3389/fonc.2019.01407
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