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Downregulation of HNRNPK in human cancer cells inhibits lung metastasis
BACKGROUND: Lung cancer frequently occurs in the clinic, leading to poor prognosis and high mortality. Markers for early diagnosis of lung cancer are scarce, and further potential therapeutic targets are also urgently needed. METHOD: We established a new mouse model in which the specific gene HNRNPK...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930993/ https://www.ncbi.nlm.nih.gov/pubmed/31942561 http://dx.doi.org/10.1002/ame2.12090 |
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author | Li, Mengyuan Zhang, Wenlong Yang, Xingjiu Liu, Hongfei Cao, Lin Li, Weisha Wang, Le Zhang, Guoxin Gao, Ran |
author_facet | Li, Mengyuan Zhang, Wenlong Yang, Xingjiu Liu, Hongfei Cao, Lin Li, Weisha Wang, Le Zhang, Guoxin Gao, Ran |
author_sort | Li, Mengyuan |
collection | PubMed |
description | BACKGROUND: Lung cancer frequently occurs in the clinic, leading to poor prognosis and high mortality. Markers for early diagnosis of lung cancer are scarce, and further potential therapeutic targets are also urgently needed. METHOD: We established a new mouse model in which the specific gene HNRNPK (heterogeneous nuclear ribonucleoprotein K) was downregulated after administration of doxycycline. The lung metastatic nodules were investigated using bioluminescence imaging, micro‐CT, and autopsy quantification. RESULTS: Compared with the short hairpin negative control group, less lung metastatic nodules were formed in the short hairpin RNA group. CONCLUSION: Downregulation of HNRNPK in cancer cells can inhibit lung metastasis. |
format | Online Article Text |
id | pubmed-6930993 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-69309932020-01-15 Downregulation of HNRNPK in human cancer cells inhibits lung metastasis Li, Mengyuan Zhang, Wenlong Yang, Xingjiu Liu, Hongfei Cao, Lin Li, Weisha Wang, Le Zhang, Guoxin Gao, Ran Animal Model Exp Med Original Articles BACKGROUND: Lung cancer frequently occurs in the clinic, leading to poor prognosis and high mortality. Markers for early diagnosis of lung cancer are scarce, and further potential therapeutic targets are also urgently needed. METHOD: We established a new mouse model in which the specific gene HNRNPK (heterogeneous nuclear ribonucleoprotein K) was downregulated after administration of doxycycline. The lung metastatic nodules were investigated using bioluminescence imaging, micro‐CT, and autopsy quantification. RESULTS: Compared with the short hairpin negative control group, less lung metastatic nodules were formed in the short hairpin RNA group. CONCLUSION: Downregulation of HNRNPK in cancer cells can inhibit lung metastasis. John Wiley and Sons Inc. 2019-11-21 /pmc/articles/PMC6930993/ /pubmed/31942561 http://dx.doi.org/10.1002/ame2.12090 Text en © 2019 The Authors. Animal Models and Experimental Medicine published by John Wiley & Sons Australia, Ltd on behalf of The Chinese Association for Laboratory Animal Sciences This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Li, Mengyuan Zhang, Wenlong Yang, Xingjiu Liu, Hongfei Cao, Lin Li, Weisha Wang, Le Zhang, Guoxin Gao, Ran Downregulation of HNRNPK in human cancer cells inhibits lung metastasis |
title | Downregulation of HNRNPK in human cancer cells inhibits lung metastasis |
title_full | Downregulation of HNRNPK in human cancer cells inhibits lung metastasis |
title_fullStr | Downregulation of HNRNPK in human cancer cells inhibits lung metastasis |
title_full_unstemmed | Downregulation of HNRNPK in human cancer cells inhibits lung metastasis |
title_short | Downregulation of HNRNPK in human cancer cells inhibits lung metastasis |
title_sort | downregulation of hnrnpk in human cancer cells inhibits lung metastasis |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930993/ https://www.ncbi.nlm.nih.gov/pubmed/31942561 http://dx.doi.org/10.1002/ame2.12090 |
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