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Epidemiology of inflammatory bowel disease in South America: A systematic review

BACKGROUND: The worldwide epidemiology of inflammatory bowel disease (IBD) is rapidly changing. Increasing Crohn’s disease (CD) and ulcerative colitis (UC) incidence and prevalence have been recorded in developing regions such as Asia, Africa and Eastern Europe where it was previously thought to be...

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Autores principales: Selvaratnam, Sriharan, Gullino, Santiago, Shim, Lisa, Lee, Eric, Lee, Alice, Paramsothy, Sudarshan, Leong, Rupert W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6931006/
https://www.ncbi.nlm.nih.gov/pubmed/31885427
http://dx.doi.org/10.3748/wjg.v25.i47.6866
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author Selvaratnam, Sriharan
Gullino, Santiago
Shim, Lisa
Lee, Eric
Lee, Alice
Paramsothy, Sudarshan
Leong, Rupert W
author_facet Selvaratnam, Sriharan
Gullino, Santiago
Shim, Lisa
Lee, Eric
Lee, Alice
Paramsothy, Sudarshan
Leong, Rupert W
author_sort Selvaratnam, Sriharan
collection PubMed
description BACKGROUND: The worldwide epidemiology of inflammatory bowel disease (IBD) is rapidly changing. Increasing Crohn’s disease (CD) and ulcerative colitis (UC) incidence and prevalence have been recorded in developing regions such as Asia, Africa and Eastern Europe where it was previously thought to be uncommon. Whether this is also the case in South America is not well known. Demonstration that developing regions worldwide have increasing IBD incidence would indicate that environmental change plays a significant role in the development of IBD. AIM: To report the incidence, prevalence and disease characteristics of CD and UC within the South American continent. METHODS: A systematic review was conducted by searching published studies in major international and regional databases (MEDLINE, EMBASE and Scopus) between January 1990 and December 2018. Outcomes considered were incidence, prevalence, phenotype, environmental and genetic factors, ethnicity and gender. A pair of independent reviewers screened and reviewed all identified articles. RESULTS: One hundred and sixty two citations were initially retrieved with 18 studies included in this systematic review. The majority of included studies were from Brazil (n =13, 72%). The incidence of UC ranged from 4.3-5.3/100000 person-years whilst the incidence of CD ranged from 0.74-3.5/100000 person-years. Prevalence ranged from 15.0-24.1/100000 inhabitants for UC and from 2.4-14.1/100000 inhabitants for CD. The incidence and prevalence of both UC and CD has increased significantly in Brazil over the past 21 years. Pancolitis was the most common disease distribution in patients with UC whilst colonic involvement was the most common distribution in CD. People residing in urban areas were at higher risk of developing both CD and UC. CONCLUSION: The IBD burden in South America is increasing at a rate possibly even greater than other developing regions around the world. There is a paucity of high-quality epidemiological studies and further robust and representative data are required to further explore modifiable risk factors and disease phenotypes.
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spelling pubmed-69310062019-12-27 Epidemiology of inflammatory bowel disease in South America: A systematic review Selvaratnam, Sriharan Gullino, Santiago Shim, Lisa Lee, Eric Lee, Alice Paramsothy, Sudarshan Leong, Rupert W World J Gastroenterol Systematic Reviews BACKGROUND: The worldwide epidemiology of inflammatory bowel disease (IBD) is rapidly changing. Increasing Crohn’s disease (CD) and ulcerative colitis (UC) incidence and prevalence have been recorded in developing regions such as Asia, Africa and Eastern Europe where it was previously thought to be uncommon. Whether this is also the case in South America is not well known. Demonstration that developing regions worldwide have increasing IBD incidence would indicate that environmental change plays a significant role in the development of IBD. AIM: To report the incidence, prevalence and disease characteristics of CD and UC within the South American continent. METHODS: A systematic review was conducted by searching published studies in major international and regional databases (MEDLINE, EMBASE and Scopus) between January 1990 and December 2018. Outcomes considered were incidence, prevalence, phenotype, environmental and genetic factors, ethnicity and gender. A pair of independent reviewers screened and reviewed all identified articles. RESULTS: One hundred and sixty two citations were initially retrieved with 18 studies included in this systematic review. The majority of included studies were from Brazil (n =13, 72%). The incidence of UC ranged from 4.3-5.3/100000 person-years whilst the incidence of CD ranged from 0.74-3.5/100000 person-years. Prevalence ranged from 15.0-24.1/100000 inhabitants for UC and from 2.4-14.1/100000 inhabitants for CD. The incidence and prevalence of both UC and CD has increased significantly in Brazil over the past 21 years. Pancolitis was the most common disease distribution in patients with UC whilst colonic involvement was the most common distribution in CD. People residing in urban areas were at higher risk of developing both CD and UC. CONCLUSION: The IBD burden in South America is increasing at a rate possibly even greater than other developing regions around the world. There is a paucity of high-quality epidemiological studies and further robust and representative data are required to further explore modifiable risk factors and disease phenotypes. Baishideng Publishing Group Inc 2019-12-21 2019-12-21 /pmc/articles/PMC6931006/ /pubmed/31885427 http://dx.doi.org/10.3748/wjg.v25.i47.6866 Text en ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Systematic Reviews
Selvaratnam, Sriharan
Gullino, Santiago
Shim, Lisa
Lee, Eric
Lee, Alice
Paramsothy, Sudarshan
Leong, Rupert W
Epidemiology of inflammatory bowel disease in South America: A systematic review
title Epidemiology of inflammatory bowel disease in South America: A systematic review
title_full Epidemiology of inflammatory bowel disease in South America: A systematic review
title_fullStr Epidemiology of inflammatory bowel disease in South America: A systematic review
title_full_unstemmed Epidemiology of inflammatory bowel disease in South America: A systematic review
title_short Epidemiology of inflammatory bowel disease in South America: A systematic review
title_sort epidemiology of inflammatory bowel disease in south america: a systematic review
topic Systematic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6931006/
https://www.ncbi.nlm.nih.gov/pubmed/31885427
http://dx.doi.org/10.3748/wjg.v25.i47.6866
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