Non-toxic HSC Transplantation-Based Macrophage/Microglia-Mediated GDNF Delivery for Parkinson’s Disease

Glial cell-line-derived neurotrophic factor (GDNF) is a potent neuroprotective agent in cellular and animal models of Parkinson’s disease (PD). However, CNS delivery of GDNF in clinical trials has proven challenging due to blood-brain barrier (BBB) impermeability, poor diffusion within brain tissue,...

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Detalles Bibliográficos
Autores principales: Chen, Cang, Guderyon, Michael J., Li, Yang, Ge, Guo, Bhattacharjee, Anindita, Ballard, Cori, He, Zhixu, Masliah, Eliezer, Clark, Robert A., O’Connor, Jason C., Li, Senlin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6931095/
https://www.ncbi.nlm.nih.gov/pubmed/31890743
http://dx.doi.org/10.1016/j.omtm.2019.11.013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6931095/
https://www.ncbi.nlm.nih.gov/pubmed/31890743
http://dx.doi.org/10.1016/j.omtm.2019.11.013

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