Cellular IP(6) Levels Limit HIV Production while Viruses that Cannot Efficiently Package IP(6) Are Attenuated for Infection and Replication

HIV-1 hijacks host proteins to promote infection. Here we show that HIV is also dependent upon the host metabolite inositol hexakisphosphate (IP(6)) for viral production and primary cell replication. HIV-1 recruits IP(6) into virions using two lysine rings in its immature hexamers. Mutation of eithe...

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Detalles Bibliográficos
Autores principales: Mallery, Donna L., Faysal, K.M. Rifat, Kleinpeter, Alex, Wilson, Miranda S.C., Vaysburd, Marina, Fletcher, Adam J., Novikova, Mariia, Böcking, Till, Freed, Eric O., Saiardi, Adolfo, James, Leo C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6931105/
https://www.ncbi.nlm.nih.gov/pubmed/31851928
http://dx.doi.org/10.1016/j.celrep.2019.11.050

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6931105/
https://www.ncbi.nlm.nih.gov/pubmed/31851928
http://dx.doi.org/10.1016/j.celrep.2019.11.050

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