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Cellular IP(6) Levels Limit HIV Production while Viruses that Cannot Efficiently Package IP(6) Are Attenuated for Infection and Replication
HIV-1 hijacks host proteins to promote infection. Here we show that HIV is also dependent upon the host metabolite inositol hexakisphosphate (IP(6)) for viral production and primary cell replication. HIV-1 recruits IP(6) into virions using two lysine rings in its immature hexamers. Mutation of eithe...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cell Press
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6931105/ https://www.ncbi.nlm.nih.gov/pubmed/31851928 http://dx.doi.org/10.1016/j.celrep.2019.11.050 |